Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test

Donald O. Freytes, Ann E. Rundell, Jonathan Vande Geest, David A. Vorp, Thomas J. Webster, Stephen F. Badylak

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Xenogeneic extracellular matrices (ECMs) have been shown to be effective as naturally occurring scaffolds for soft-tissue repair. As acellular tissue substitutes at the time of surgical implantation, ECMs are subjected to the mechanical forces and micro-environmental conditions representative of the anatomical location in which they are placed. Ideally such natural scaffolds would possess mechanical properties that allow for normal tissue function in and around the implant site. The ball-burst test was used to simulate biaxial forces and to determine the strength of the ECM scaffold under a relevant physiological loading condition. The ball-burst test, in itself, does not quantify intrinsic mechanical properties and therefore a methodology was developed to determine the maximum stress resultant tangent modulus (MSRTM) or the maximum stress tangent modulus (MSTM), stress to failure (σf), failure stress resultant (Nf), ball-burst pressure (P), and maximum elongation (λmax) from the raw ball-burst data obtained at a constant-rate of transverse. The analytical methodology was compared to finite element simulations and showed good correlation with the analytical solution presented. The proposed approximations were used to compute biaxial failure properties for a variety of multilaminate ECM devices with varying number of layers, disinfection and sterilization, and organ origin.

Original languageEnglish (US)
Pages (from-to)5518-5531
Number of pages14
JournalBiomaterials
Volume26
Issue number27
DOIs
StatePublished - Sep 2005

Keywords

  • Ball-burst test
  • Bladder
  • ECM
  • Mechanical properties
  • Mechanical test
  • Multilaminate devices
  • Scaffold

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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