Anamnestic studies in multiple sclerosis: A relationship between familial multiple sclerosis and neoplasia

W. A. Sibley, C. R. Bamford, J. F. Laguna

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A survey of family histories of malignant neoplasia in multiple sclerosis (MS) patients indicates that a positive history of cancer in near relatives is present in 44% of patients and 46% of controls. However, those MS patients having such a positive history were much more likely than others to also have a family history of MS. Contrariwise, MS patients with a positive family history of MS had a significantly higher rate of cancer in first degree relatives (71%) than others. There was a trend indicating less cancer in families of MS patients possessing the HLA-B7 and DW2 histocompatibility antigens.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeurology
Volume28
Issue number9 II
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Clinical Neurology

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