Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms

S. R. Kim, N. Vora, T. G. Jovin, R. Gupta, A. Thomas, A. Kassam, K. Lee, Y. Gologorsky, B. Jankowitz, N. Panapitiya, A. Aleu, E. Sandhu, E. Crago, A. Hricik, Matthew J Gallek, Michael B. Horowitz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The purpose of this study was to evaluate and report our anatomic results and complications associated with stent-assisted coil embolization of intracranial aneurysms using the Neuroform stent. From September 2003 to August 2007, 127 consecutive patients (ruptured 50, 39.4%; unruptured 77, 60.6%) underwent 129 stent-assisted coil embolization procedures to treat 136 aneurysms at our institution. Anatomic results at follow-up, procedure-related complications, and morbidity/mortality were retrospectively reviewed. Stent deployment was successful in 128 out of 129 procedures (99.2%). Forty-seven patients presented with 53 procedure-related complications (37.0%, 47/127). Thromboembolic events (n=17, 13.4%) were the most common complications, followed by intraoperative rupture (n=8, 6.3%), coil herniation (n=5, 3.9%), and postoperative rupture (n=4, 3.1%). For thromboembolic events, acute intra-procedural instent thromboses were observed in two patients and subacute or delayed in-stent thromboses in three patients. Overall mortality rate was 16.5% (21/127) and procedure-related morbidity and mortality rates were 5.5% (7/127) and 8.7% (11/127) retrospectively. Patients with poor grade subarachnoid hemorrhage (Hunt and Hess grade IV or V; 25/127, 19.7%) exhibited 56% (14/25) overall mortality rate and 24% (6/25) procedure-related mortality rate. Immediate angiographic results showed complete occlusion in 31.7% of aneurysms, near-complete occlusion in 45.5%, and partial occlusion in 22.8%. Sixty nine patients in 70 procedures with 77 aneurysms underwent angiographic follow-up at six months or later. Mean follow-up period was 13.7 months (6 to 45 months). Complete occlusion was observed in 57 aneurysms (74.0%) and significant in-stent stenosis was not found. Thromboembolism and intra/postoperative aneurysm ruptures were the most common complications and the main causes of procedure-related morbidity and mortality. Patients with poor grade subarachnoid hemorrhage showed poor clinical outcomes. Since most complications were induced by stent manipulation and deployment, it is mandatory to utilize these devices selectively and cautiously. While the follow-up angiographic results are promising, further studies are essential to evaluate safety, efficacy, and durability of the Neuroform stent.

Original languageEnglish (US)
Pages (from-to)267-284
Number of pages18
JournalInterventional Neuroradiology
Volume14
Issue number3
StatePublished - Sep 2008
Externally publishedYes

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Intracranial Aneurysm
Stents
Aneurysm
Mortality
Rupture
Subarachnoid Hemorrhage
Morbidity
Thrombosis
Thromboembolism
Intraoperative Complications
Pathologic Constriction
Safety
Equipment and Supplies

Keywords

  • Aneurysm
  • Coil
  • Complication
  • Neuroform
  • Stent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, S. R., Vora, N., Jovin, T. G., Gupta, R., Thomas, A., Kassam, A., ... Horowitz, M. B. (2008). Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms. Interventional Neuroradiology, 14(3), 267-284.

Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms. / Kim, S. R.; Vora, N.; Jovin, T. G.; Gupta, R.; Thomas, A.; Kassam, A.; Lee, K.; Gologorsky, Y.; Jankowitz, B.; Panapitiya, N.; Aleu, A.; Sandhu, E.; Crago, E.; Hricik, A.; Gallek, Matthew J; Horowitz, Michael B.

In: Interventional Neuroradiology, Vol. 14, No. 3, 09.2008, p. 267-284.

Research output: Contribution to journalArticle

Kim, SR, Vora, N, Jovin, TG, Gupta, R, Thomas, A, Kassam, A, Lee, K, Gologorsky, Y, Jankowitz, B, Panapitiya, N, Aleu, A, Sandhu, E, Crago, E, Hricik, A, Gallek, MJ & Horowitz, MB 2008, 'Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms', Interventional Neuroradiology, vol. 14, no. 3, pp. 267-284.
Kim SR, Vora N, Jovin TG, Gupta R, Thomas A, Kassam A et al. Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms. Interventional Neuroradiology. 2008 Sep;14(3):267-284.
Kim, S. R. ; Vora, N. ; Jovin, T. G. ; Gupta, R. ; Thomas, A. ; Kassam, A. ; Lee, K. ; Gologorsky, Y. ; Jankowitz, B. ; Panapitiya, N. ; Aleu, A. ; Sandhu, E. ; Crago, E. ; Hricik, A. ; Gallek, Matthew J ; Horowitz, Michael B. / Anatomic results and complications of stent-assisted coil embolization of intracranial aneurysms. In: Interventional Neuroradiology. 2008 ; Vol. 14, No. 3. pp. 267-284.
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abstract = "The purpose of this study was to evaluate and report our anatomic results and complications associated with stent-assisted coil embolization of intracranial aneurysms using the Neuroform stent. From September 2003 to August 2007, 127 consecutive patients (ruptured 50, 39.4{\%}; unruptured 77, 60.6{\%}) underwent 129 stent-assisted coil embolization procedures to treat 136 aneurysms at our institution. Anatomic results at follow-up, procedure-related complications, and morbidity/mortality were retrospectively reviewed. Stent deployment was successful in 128 out of 129 procedures (99.2{\%}). Forty-seven patients presented with 53 procedure-related complications (37.0{\%}, 47/127). Thromboembolic events (n=17, 13.4{\%}) were the most common complications, followed by intraoperative rupture (n=8, 6.3{\%}), coil herniation (n=5, 3.9{\%}), and postoperative rupture (n=4, 3.1{\%}). For thromboembolic events, acute intra-procedural instent thromboses were observed in two patients and subacute or delayed in-stent thromboses in three patients. Overall mortality rate was 16.5{\%} (21/127) and procedure-related morbidity and mortality rates were 5.5{\%} (7/127) and 8.7{\%} (11/127) retrospectively. Patients with poor grade subarachnoid hemorrhage (Hunt and Hess grade IV or V; 25/127, 19.7{\%}) exhibited 56{\%} (14/25) overall mortality rate and 24{\%} (6/25) procedure-related mortality rate. Immediate angiographic results showed complete occlusion in 31.7{\%} of aneurysms, near-complete occlusion in 45.5{\%}, and partial occlusion in 22.8{\%}. Sixty nine patients in 70 procedures with 77 aneurysms underwent angiographic follow-up at six months or later. Mean follow-up period was 13.7 months (6 to 45 months). Complete occlusion was observed in 57 aneurysms (74.0{\%}) and significant in-stent stenosis was not found. Thromboembolism and intra/postoperative aneurysm ruptures were the most common complications and the main causes of procedure-related morbidity and mortality. Patients with poor grade subarachnoid hemorrhage showed poor clinical outcomes. Since most complications were induced by stent manipulation and deployment, it is mandatory to utilize these devices selectively and cautiously. While the follow-up angiographic results are promising, further studies are essential to evaluate safety, efficacy, and durability of the Neuroform stent.",
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