Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults

K. Walther, B. B. Bendlin, Elizabeth L Glisky, Theodore "Ted" Trouard, Jeffrey R Lisse, J. O. Posever, T Lee Ryan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.

Original languageEnglish (US)
Pages (from-to)497-505
Number of pages9
JournalNeurobiology of Aging
Volume32
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Anti-Inflammatory Agents
Brain
Pharmaceutical Preparations
Drug Users
Temporal Lobe
Prefrontal Cortex
Parahippocampal Gyrus
Mesencephalon
Arthritis
Alzheimer Disease
Inflammation
Education
Pain
White Matter
Gray Matter

Keywords

  • Aging
  • Alzheimer's disease
  • Anti-inflammatory agents
  • Magnetic resonance imaging
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults. / Walther, K.; Bendlin, B. B.; Glisky, Elizabeth L; Trouard, Theodore "Ted"; Lisse, Jeffrey R; Posever, J. O.; Ryan, T Lee.

In: Neurobiology of Aging, Vol. 32, No. 3, 03.2011, p. 497-505.

Research output: Contribution to journalArticle

@article{e6110628666e47e6bca5d2987bfe3a27,
title = "Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults",
abstract = "Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.",
keywords = "Aging, Alzheimer's disease, Anti-inflammatory agents, Magnetic resonance imaging, Voxel-based morphometry",
author = "K. Walther and Bendlin, {B. B.} and Glisky, {Elizabeth L} and Trouard, {Theodore {"}Ted{"}} and Lisse, {Jeffrey R} and Posever, {J. O.} and Ryan, {T Lee}",
year = "2011",
month = "3",
doi = "10.1016/j.neurobiolaging.2009.03.006",
language = "English (US)",
volume = "32",
pages = "497--505",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults

AU - Walther, K.

AU - Bendlin, B. B.

AU - Glisky, Elizabeth L

AU - Trouard, Theodore "Ted"

AU - Lisse, Jeffrey R

AU - Posever, J. O.

AU - Ryan, T Lee

PY - 2011/3

Y1 - 2011/3

N2 - Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.

AB - Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.

KW - Aging

KW - Alzheimer's disease

KW - Anti-inflammatory agents

KW - Magnetic resonance imaging

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=79952898339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952898339&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2009.03.006

DO - 10.1016/j.neurobiolaging.2009.03.006

M3 - Article

VL - 32

SP - 497

EP - 505

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 3

ER -