Anti-inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials

Reem Faraj, Danyelle Paine, Stephen M. Black, Ting Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

HMG-CoA reductase inhibitors (or statins) are cholesterol-lowering drugs and are among the most widely prescribed medications in the United States. Statins exhibit pleiotropic effects that extend beyond cholesterol reduction including anti-atherosclerotic, antiproliferative, anti-inflammatory, and antithrombotic effects. Over the last 20 years, statins have been studied and examined in pulmonary vascular disorders, including both chronic pulmonary vascular disease such as pulmonary hypertension, and acute pulmonary vascular endothelial injury such as acute lung injury. In both research and clinical settings, statins have demonstrated promising vascular protection through modulation of the endothelium, attenuation of vascular leak, and promotion of endothelial repair following lung inflammation. This chapter provides a summary of the rapidly changing literature, summarizes the anti-inflammatory mechanism of statins on pulmonary vascular disorders, and explores clinical evidence for statins as a potential therapeutic approach to modulation of the endothelium as well as a means to broaden our understanding of pulmonary vasculopathy pathophysiology.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages33-56
Number of pages24
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1303
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Endothelial
  • HMG-CoA reductase inhibitors
  • Mortality
  • Pulmonary hypertension
  • Statin
  • Vascular leak

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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