Anti-inflammatory effects of theophylline: Modulation of immune functions during murine leukemia virus infection

Bailin Liang, Shuguang Jiang, Zhen Zhang, Paula Inserra, Jeongmin Lee, David Solkoff, Ronald R. Watson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.

Original languageEnglish (US)
Pages (from-to)307-319
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Volume23
Issue number3
DOIs
StatePublished - Nov 15 2001

Keywords

  • Apoptosis
  • Cytokine
  • Immune dysfunction
  • Murine retrovirus
  • T and B cell proliferation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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