Antiarrhythmic efficacy of desipramine

Paul E Fenster, R. Bressler, J. Kipps

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single-blind, placebo-controlled, dose-ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, based on three 24 hour ambulatory ECGs obtained on each dose. Among seven patients with analyzable data, one responded to 75 mg daily, and three others responded to 150 mg daily. Six of the seven patients demonstrated decreases in VED frequency with increases in desipramine serum concentration. Among five patients with episodes of nonsustained ventricular tachycardia, desipramine completely abolished the episodes in two, and reduced the frequency of episodes by at least 90% in two others. Adverse reactions were common, and necessitated drug discontinuation or dose reduction in five patients. Desipramine has an antiarrhythmic effect in patients with chronic ventricular ectopy, but its clinical utility is limited by adverse effects.

Original languageEnglish (US)
Pages (from-to)114-117
Number of pages4
JournalJournal of Clinical Pharmacology
Volume29
Issue number2
StatePublished - 1989

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Desipramine
Ventricular Tachycardia
Electrocardiography
Placebos
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Fenster, P. E., Bressler, R., & Kipps, J. (1989). Antiarrhythmic efficacy of desipramine. Journal of Clinical Pharmacology, 29(2), 114-117.

Antiarrhythmic efficacy of desipramine. / Fenster, Paul E; Bressler, R.; Kipps, J.

In: Journal of Clinical Pharmacology, Vol. 29, No. 2, 1989, p. 114-117.

Research output: Contribution to journalArticle

Fenster, PE, Bressler, R & Kipps, J 1989, 'Antiarrhythmic efficacy of desipramine', Journal of Clinical Pharmacology, vol. 29, no. 2, pp. 114-117.
Fenster, Paul E ; Bressler, R. ; Kipps, J. / Antiarrhythmic efficacy of desipramine. In: Journal of Clinical Pharmacology. 1989 ; Vol. 29, No. 2. pp. 114-117.
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