Antibiotics and anaerobes of gut origin

Gayatri Vedantam, David W. Hecht

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Hundreds of bacterial species make up human gut flora. Of these, 99% are anaerobic bacteria. Although anaerobes are part of the normal commensal flora, they can become opportunistic pathogens, causing serious, sometimes fatal infections if they escape from the colonic milieu. Most often, this escape occurs as a result of perforation, surgery, diverticulitis or cancer. Infections involving anaerobic bacteria are often difficult to treat because antibiotic resistance is increasing among the genera, mediated primarily through horizontal transfer of a plethora of mobile DNA transfer factors. Some of these transfer factors can also be transmitted to aerobic bacteria. It is becoming increasingly clear that antibiotic resistance trends have to be carefully monitored, and the transfer factors and mechanisms of transfer understood at a molecular level to avoid negative clinical outcomes when infections involve anaerobic bacteria.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalCurrent Opinion in Microbiology
Volume6
Issue number5
DOIs
StatePublished - Oct 2003
Externally publishedYes

Fingerprint

Transfer Factor
Anaerobic Bacteria
Microbial Drug Resistance
Anti-Bacterial Agents
Infection
Diverticulitis
Aerobic Bacteria
DNA
Neoplasms

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

Antibiotics and anaerobes of gut origin. / Vedantam, Gayatri; Hecht, David W.

In: Current Opinion in Microbiology, Vol. 6, No. 5, 10.2003, p. 457-461.

Research output: Contribution to journalArticle

Vedantam, Gayatri ; Hecht, David W. / Antibiotics and anaerobes of gut origin. In: Current Opinion in Microbiology. 2003 ; Vol. 6, No. 5. pp. 457-461.
@article{e30e3dbda519496fb7b7db21900ee1fa,
title = "Antibiotics and anaerobes of gut origin",
abstract = "Hundreds of bacterial species make up human gut flora. Of these, 99{\%} are anaerobic bacteria. Although anaerobes are part of the normal commensal flora, they can become opportunistic pathogens, causing serious, sometimes fatal infections if they escape from the colonic milieu. Most often, this escape occurs as a result of perforation, surgery, diverticulitis or cancer. Infections involving anaerobic bacteria are often difficult to treat because antibiotic resistance is increasing among the genera, mediated primarily through horizontal transfer of a plethora of mobile DNA transfer factors. Some of these transfer factors can also be transmitted to aerobic bacteria. It is becoming increasingly clear that antibiotic resistance trends have to be carefully monitored, and the transfer factors and mechanisms of transfer understood at a molecular level to avoid negative clinical outcomes when infections involve anaerobic bacteria.",
author = "Gayatri Vedantam and Hecht, {David W.}",
year = "2003",
month = "10",
doi = "10.1016/j.mib.2003.09.006",
language = "English (US)",
volume = "6",
pages = "457--461",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Antibiotics and anaerobes of gut origin

AU - Vedantam, Gayatri

AU - Hecht, David W.

PY - 2003/10

Y1 - 2003/10

N2 - Hundreds of bacterial species make up human gut flora. Of these, 99% are anaerobic bacteria. Although anaerobes are part of the normal commensal flora, they can become opportunistic pathogens, causing serious, sometimes fatal infections if they escape from the colonic milieu. Most often, this escape occurs as a result of perforation, surgery, diverticulitis or cancer. Infections involving anaerobic bacteria are often difficult to treat because antibiotic resistance is increasing among the genera, mediated primarily through horizontal transfer of a plethora of mobile DNA transfer factors. Some of these transfer factors can also be transmitted to aerobic bacteria. It is becoming increasingly clear that antibiotic resistance trends have to be carefully monitored, and the transfer factors and mechanisms of transfer understood at a molecular level to avoid negative clinical outcomes when infections involve anaerobic bacteria.

AB - Hundreds of bacterial species make up human gut flora. Of these, 99% are anaerobic bacteria. Although anaerobes are part of the normal commensal flora, they can become opportunistic pathogens, causing serious, sometimes fatal infections if they escape from the colonic milieu. Most often, this escape occurs as a result of perforation, surgery, diverticulitis or cancer. Infections involving anaerobic bacteria are often difficult to treat because antibiotic resistance is increasing among the genera, mediated primarily through horizontal transfer of a plethora of mobile DNA transfer factors. Some of these transfer factors can also be transmitted to aerobic bacteria. It is becoming increasingly clear that antibiotic resistance trends have to be carefully monitored, and the transfer factors and mechanisms of transfer understood at a molecular level to avoid negative clinical outcomes when infections involve anaerobic bacteria.

UR - http://www.scopus.com/inward/record.url?scp=0242323602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242323602&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2003.09.006

DO - 10.1016/j.mib.2003.09.006

M3 - Article

VL - 6

SP - 457

EP - 461

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 5

ER -