Antibodies to tumor necrosis factor

a component of B cell immune responses with a role in tumor/host interaction

José Alexandre M Barbuto, William J. Grimes, Evan M Hersh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Infiltrating B lymphocytes are found within tumors, where their role and the antigens they recognize are poorly defined. After in vitro expansion of these cells, we were able to detect the production of antibodies to tumor necrosis factor α (TNF) in 13 of 17 human tumors studied. These antibodies were detected by both enzyme-linked immunosorbent assay and by neutralization. Anti-TNF antibodies were not produced by resting peripheral blood B cells of normal subjects. However, anti-TNF antibodies were produced by B cells obtained from healthy individuals, after either in vivo or in vitro antigenic stimulation. This suggests that anti-TNF antibody production may constitute part of the overall B cell response to antigens. The intratumoral production of anti-TNF antibody may play a role in tumor/host interactions.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalCancer Immunology, Immunotherapy
Volume40
Issue number1
DOIs
StatePublished - Jan 1995
Externally publishedYes

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B-Lymphocytes
Tumor Necrosis Factor-alpha
Antibodies
Neoplasms
Antibody Formation
Antigens
Blood Cells
Enzyme-Linked Immunosorbent Assay
In Vitro Techniques

Keywords

  • TNF
  • Tumor necrosis factor
  • Tumor-infiltrating lymphocytes B lymphocytes

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

Cite this

Antibodies to tumor necrosis factor : a component of B cell immune responses with a role in tumor/host interaction. / Barbuto, José Alexandre M; Grimes, William J.; Hersh, Evan M.

In: Cancer Immunology, Immunotherapy, Vol. 40, No. 1, 01.1995, p. 31-36.

Research output: Contribution to journalArticle

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