Antibodies to tumor necrosis factor: a component of B cell immune responses with a role in tumor/host interaction

José Alexandre M. Barbuto, William J. Grimes, Evan M. Hersh

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Infiltrating B lymphocytes are found within tumors, where their role and the antigens they recognize are poorly defined. After in vitro expansion of these cells, we were able to detect the production of antibodies to tumor necrosis factor α (TNF) in 13 of 17 human tumors studied. These antibodies were detected by both enzyme-linked immunosorbent assay and by neutralization. Anti-TNF antibodies were not produced by resting peripheral blood B cells of normal subjects. However, anti-TNF antibodies were produced by B cells obtained from healthy individuals, after either in vivo or in vitro antigenic stimulation. This suggests that anti-TNF antibody production may constitute part of the overall B cell response to antigens. The intratumoral production of anti-TNF antibody may play a role in tumor/host interactions.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalCancer Immunology Immunotherapy
Volume40
Issue number1
DOIs
StatePublished - Jan 1 1995

Keywords

  • TNF
  • Tumor necrosis factor
  • Tumor-infiltrating lymphocytes B lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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