Antidepressant treatment of cytokine-induced mood disorders

Charles L. Raison, Michael Marcin, Andrew H. Miller

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Significant evidence suggests that the immune system is capable of profoundly affecting central nervous system (CNS) functioning in ways that may contribute to the development and expression of neuropsychiatric disorders, including disorders of mood. This paper reviews evidence that the production of proinflammatory cytokines, whether in the context of therapeutic administration (e.g. interferonα-2b for hepatitis C infection) or medical illness, induces a state of sickness behavior that closely resembles major depression. Antidepressants have been shown to abolish or attenuate cytokineinduced sickness behavior in laboratory animals and to protect against the development of major depression in the context of therapeutic cytokine administration in humans. Potential mechanisms by which antidepressants ameliorate depressive and/or sickness symptoms in the context of immune activation include direct effects on immune cell functioning, as well as modulatory effects on monoamine neurotransmitters, intracellular second messenger pathways and the neuroendocrine system, in particular the hypothalamic - pituitary - adrenal axis.

Original languageEnglish (US)
Pages (from-to)336-343
Number of pages8
JournalActa Neuropsychiatrica
Volume14
Issue number6
DOIs
StatePublished - Dec 2002

Keywords

  • Antidepressant
  • Cytokines
  • Immune
  • Mood disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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