Antidote studies of vinorelbine-induced skin ulceration in the mouse

Robert T. Dorr, Kristi L. Bool

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The new cantharanthine-modified vinca alkaloid vinorelbine (Navelbine) was administered intradermally (ID) to dehaired BALB/c mice. Dose-dependent skin lesions were produced over the range 0.01-0.5 mg/mouse, with complete healing after 9-35 days. Local (ID) injections of hydrocortisone and saline were ineffective at blocking vinorelbine-induced skin ulceration. Topical skin heating to 43°C or cooling to 10°C were also ineffective. In contrast, hyaluronidase, 15 Units ID, following vinorelbine significantly reduced skin lesions. These results show that vinorelbine is a vesicant and that inadvertent extravasations may be managed with subcutaneous injection of the spreading factor enzyme, hyaluronidase.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalCancer Chemotherapy And Pharmacology
Volume36
Issue number4
DOIs
StatePublished - Jul 1 1995

Keywords

  • Extravasation
  • Vinca alkaloid

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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