Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species

Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, Xiaoyi Wei

Research output: Research - peer-reviewArticle

Abstract

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV (7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5′-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

LanguageEnglish (US)
Pages2215-2253
Number of pages39
JournalJournal of Natural Products
Volume80
Issue number8
DOIs
StatePublished - Aug 25 2017

Fingerprint

Paecilomyces
Lactones
beta-resorcylic acid
Acids
Keto Acids
MCF-7 Cells
HeLa Cells
X-Ray Diffraction
A549 Cells
monorden
hypothemycin
monocillin I
Spectroscopic analysis
Cytotoxicity
Metabolites
X ray diffraction analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. / Xu, Liangxiong; Wu, Ping; Xue, Jinghua; Molnar, Istvan; Wei, Xiaoyi.

In: Journal of Natural Products, Vol. 80, No. 8, 25.08.2017, p. 2215-2253.

Research output: Research - peer-reviewArticle

Xu, Liangxiong ; Wu, Ping ; Xue, Jinghua ; Molnar, Istvan ; Wei, Xiaoyi. / Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. In: Journal of Natural Products. 2017 ; Vol. 80, No. 8. pp. 2215-2253
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