Antigen solubilized from human leukemia: Lymphocyte stimulation

Jordan U. Gutterman, Giora Mavligit, Kenneth B. McCredie, Gerald P. Bodey, Emil J. Freireich, Evan M. Hersh

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Abstract

Soluble antigen was extracted with hypertonic (3 molar) potassium chloride from the malignant cells of seven patients with acute leukemnia. The antigen and leukemia cells were used to stimulate autologous patients' and allogeneic normal donors' lymphocytes in mixed lymphocyte cultuires. The lymphocytes of six patients showed significant blastogenic responses to autologolus antigen. In contrast, the lymphocytes of only one of seven normal donors responded to the soluble antigens. Both patients' and normal subjects' lymphocytes responded to the intact leukemia cells. The use of these antigens should facilitate the study of specific tumor immunity in human leukemia.

Original languageEnglish (US)
Pages (from-to)1114-1115
Number of pages2
JournalScience
Volume177
Issue number4054
DOIs
StatePublished - Jan 1 1972

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    Gutterman, J. U., Mavligit, G., McCredie, K. B., Bodey, G. P., Freireich, E. J., & Hersh, E. M. (1972). Antigen solubilized from human leukemia: Lymphocyte stimulation. Science, 177(4054), 1114-1115. https://doi.org/10.1126/science.177.4054.1114