Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Ajith P.K. Nissanka, Veranja Karunaratne, B. M.Ratnayake Bandara, Vijaya Kumar, Tsutomu Nakanishi, Masatoshi Nishi, Akira Inada, L. M.V. Tillekeratne, D. S.A. Wijesundara, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalPhytochemistry
Volume56
Issue number8
DOIs
StatePublished - Apr 12 2001

Keywords

  • 8-Acetonyldihydroavicine
  • 8-Acetonyldihydronitidine
  • Antimicrobial
  • Benzophenanthrene alkaloids
  • Insecticidal
  • Rutaceae
  • Spermicidal
  • Z. caudatum
  • Zanthoxylum tetraspermum

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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  • Cite this

    Nissanka, A. P. K., Karunaratne, V., Bandara, B. M. R., Kumar, V., Nakanishi, T., Nishi, M., Inada, A., Tillekeratne, L. M. V., Wijesundara, D. S. A., & Gunatilaka, A. A. L. (2001). Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry, 56(8), 857-861. https://doi.org/10.1016/S0031-9422(00)00402-7