Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Ajith P K Nissanka, Veranja Karunaratne, B. M Ratnayake Bandara, Vijaya Kumar, Tsutomu Nakanishi, Masatoshi Nishi, Akira Inada, L. M V Tillekeratne, D. S A Wijesundara, Leslie Gunatilaka

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalPhytochemistry
Volume56
Issue number8
DOIs
StatePublished - Apr 12 2001

Fingerprint

Zanthoxylum
Urodela
Caudata
Sri Lanka
Alkaloids
alkaloids
bark
indigenous species
anti-infective agents
stems
sesamin
savinin
liriodenine
8-acetonyldihydroavicine
8-acetonyldihydronitidine

Keywords

  • 8-Acetonyldihydroavicine
  • 8-Acetonyldihydronitidine
  • Antimicrobial
  • Benzophenanthrene alkaloids
  • Insecticidal
  • Rutaceae
  • Spermicidal
  • Z. caudatum
  • Zanthoxylum tetraspermum

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Nissanka, A. P. K., Karunaratne, V., Bandara, B. M. R., Kumar, V., Nakanishi, T., Nishi, M., ... Gunatilaka, L. (2001). Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry, 56(8), 857-861. https://doi.org/10.1016/S0031-9422(00)00402-7

Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. / Nissanka, Ajith P K; Karunaratne, Veranja; Bandara, B. M Ratnayake; Kumar, Vijaya; Nakanishi, Tsutomu; Nishi, Masatoshi; Inada, Akira; Tillekeratne, L. M V; Wijesundara, D. S A; Gunatilaka, Leslie.

In: Phytochemistry, Vol. 56, No. 8, 12.04.2001, p. 857-861.

Research output: Contribution to journalArticle

Nissanka, APK, Karunaratne, V, Bandara, BMR, Kumar, V, Nakanishi, T, Nishi, M, Inada, A, Tillekeratne, LMV, Wijesundara, DSA & Gunatilaka, L 2001, 'Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum', Phytochemistry, vol. 56, no. 8, pp. 857-861. https://doi.org/10.1016/S0031-9422(00)00402-7
Nissanka APK, Karunaratne V, Bandara BMR, Kumar V, Nakanishi T, Nishi M et al. Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry. 2001 Apr 12;56(8):857-861. https://doi.org/10.1016/S0031-9422(00)00402-7
Nissanka, Ajith P K ; Karunaratne, Veranja ; Bandara, B. M Ratnayake ; Kumar, Vijaya ; Nakanishi, Tsutomu ; Nishi, Masatoshi ; Inada, Akira ; Tillekeratne, L. M V ; Wijesundara, D. S A ; Gunatilaka, Leslie. / Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. In: Phytochemistry. 2001 ; Vol. 56, No. 8. pp. 857-861.
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