Abstract
Bacteroides spp. organisms, though important human commensals, are also opportunistic pathogens when they escape the colonic milieu. Resistance to multiple antibiotics has been increasing in Bacteroides spp. for decades, and is primarily due to horizontal gene transfer of a plethora of mobile elements. The mechanistic aspects of conjugation in Bacteroides spp. are only now being elucidated at a functional level. There appear to be key differences between Bacteroides spp. and non-Bacteroides spp. conjugation systems that may contribute to promiscuous gene transfer within and from this genus. This review summarizes the mechanisms of action and resistance of antibiotics used to treat Bacteroides spp. infections, and highlights current information on conjugation-based DNA exchange.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 413-423 |
| Number of pages | 11 |
| Journal | Future Microbiology |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
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Keywords
- Anaerobe
- Antibiotic resistance
- Bacteroides
- Conjugation
- Horizontal gene transfer
- Mating apparatus
- Opportunistic pathogen
- Relaxosome
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
Cite this
Antimicrobial resistance in Bacteroides spp. Occurrence and dissemination. / Vedantam, Gayatri.
In: Future Microbiology, Vol. 4, No. 4, 2009, p. 413-423.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antimicrobial resistance in Bacteroides spp.
T2 - Occurrence and dissemination
AU - Vedantam, Gayatri
PY - 2009
Y1 - 2009
N2 - Bacteroides spp. organisms, though important human commensals, are also opportunistic pathogens when they escape the colonic milieu. Resistance to multiple antibiotics has been increasing in Bacteroides spp. for decades, and is primarily due to horizontal gene transfer of a plethora of mobile elements. The mechanistic aspects of conjugation in Bacteroides spp. are only now being elucidated at a functional level. There appear to be key differences between Bacteroides spp. and non-Bacteroides spp. conjugation systems that may contribute to promiscuous gene transfer within and from this genus. This review summarizes the mechanisms of action and resistance of antibiotics used to treat Bacteroides spp. infections, and highlights current information on conjugation-based DNA exchange.
AB - Bacteroides spp. organisms, though important human commensals, are also opportunistic pathogens when they escape the colonic milieu. Resistance to multiple antibiotics has been increasing in Bacteroides spp. for decades, and is primarily due to horizontal gene transfer of a plethora of mobile elements. The mechanistic aspects of conjugation in Bacteroides spp. are only now being elucidated at a functional level. There appear to be key differences between Bacteroides spp. and non-Bacteroides spp. conjugation systems that may contribute to promiscuous gene transfer within and from this genus. This review summarizes the mechanisms of action and resistance of antibiotics used to treat Bacteroides spp. infections, and highlights current information on conjugation-based DNA exchange.
KW - Anaerobe
KW - Antibiotic resistance
KW - Bacteroides
KW - Conjugation
KW - Horizontal gene transfer
KW - Mating apparatus
KW - Opportunistic pathogen
KW - Relaxosome
UR - http://www.scopus.com/inward/record.url?scp=66949146907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66949146907&partnerID=8YFLogxK
U2 - 10.2217/fmb.09.12
DO - 10.2217/fmb.09.12
M3 - Article
VL - 4
SP - 413
EP - 423
JO - Future Microbiology
JF - Future Microbiology
SN - 1746-0913
IS - 4
ER -