Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans

Mohsen Araghiniknam, Sangbun Chung, Tresa Nelson-White, Cleamond Eskelson, Ronald R Watson

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.

Original languageEnglish (US)
JournalLife Sciences
Volume59
Issue number11
DOIs
StatePublished - Aug 9 1996

Fingerprint

Dioscorea
Dehydroepiandrosterone
Antioxidants
Dehydroepiandrosterone Sulfate
Lipids
Steroids
Serum
Lipid Peroxidation
Phospholipids
Triglycerides
Volunteers

Keywords

  • Dehydroepiandrosterone
  • DHEA
  • Dioscorea
  • Lipids
  • Oxidative damage
  • Yam

ASJC Scopus subject areas

  • Pharmacology

Cite this

Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans. / Araghiniknam, Mohsen; Chung, Sangbun; Nelson-White, Tresa; Eskelson, Cleamond; Watson, Ronald R.

In: Life Sciences, Vol. 59, No. 11, 09.08.1996.

Research output: Contribution to journalArticle

Araghiniknam, Mohsen ; Chung, Sangbun ; Nelson-White, Tresa ; Eskelson, Cleamond ; Watson, Ronald R. / Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans. In: Life Sciences. 1996 ; Vol. 59, No. 11.
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