Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between NO and oxidative stress

Lisa A. Ridnour, Douglas D. Thomas, Daniele Mancardi, Sonia Donzelli, Nazerrano Paolocci, Pasquale Pagliaro, Katrina M. Miranda, Murali Krishna, John Fukuto, Matthew B. Grisham, James B. Mitchell, Michael G. Espey, David A. Wink

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The function of nitric oxide (NO) in pathophysiology remains confounding as both protective and cytotoxic effects of NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of NO. However, the counteracting role of NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalCurrent Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents
Volume3
Issue number3
DOIs
StatePublished - Sep 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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    Ridnour, L. A., Thomas, D. D., Mancardi, D., Donzelli, S., Paolocci, N., Pagliaro, P., Miranda, K. M., Krishna, M., Fukuto, J., Grisham, M. B., Mitchell, J. B., Espey, M. G., & Wink, D. A. (2004). Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between NO and oxidative stress. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, 3(3), 181-188. https://doi.org/10.2174/1568014043355311