Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice

Jin Zhang, Shuguang Jiang, Ronald R. Watson

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with pathology in cardiovascular disease and conditions that have an inflammatory base. Exposure to SSCS through a burning cigarette for 30 min/day, 5 days a week, for 4 months increased interleukin-6 production in spleen and lipid peroxide level in mouse liver. Our findings suggest that ROS induced by SSCS will promote hepatic lipid peroxidation and may also contribute to an increase in interleukin-6 cytokine production. Multiple antioxidants given as a dietary supplement significantly normalized interleukin-6 cytokine production and prevented hepatic lipid peroxidation. We conclude that the SSCS in moderate intake levels increased oxidation and promoted inflammatory cytokine interleukin-6 production, whereas antioxidants prevented these changes.

Original languageEnglish (US)
Pages (from-to)1007-1009
Number of pages3
JournalEnvironmental health perspectives
Volume109
Issue number10
DOIs
StatePublished - Jan 1 2001

Keywords

  • Antioxidants
  • Interleukin-6
  • Lipid peroxidation
  • Sidestream cigarette smoke

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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