Antioxidants and AIDS

Zhen Zhang, Paula Inserra, Bailin Liang, Ronald R Watson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acquired immunodeficiency syndrome (AIDS) is a result of infection with human immunodeficiency virus (HIV-1 or HIV-2) which eventually destroys subset CD4+ helper T lymphocytes. This results in enhanced susceptibility to opportunistic infection and neoplasms. Oxidative stress plays a major role in the progression of HIV infection to AIDS and has been suggested to contribute to the decline in CD4+ lymphocytes. The existence of oxidative stress in HIV infection and AIDS is exemplified by the excess production of reactive oxygen species (ROS) and a general loss of antioxidant defenses in HIV-infected patients. Therefore, the reduction of oxidative stress by antioxidant treatment may be a desirable therapy during the asymptotic HIV infection as well as advanced AIDS.

Original languageEnglish (US)
Title of host publicationNutrients and Foods in Aids
PublisherCRC Press
Pages179-192
Number of pages14
ISBN (Electronic)9781351427432
ISBN (Print)084938561X, 9780849385612
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Zhang, Z., Inserra, P., Liang, B., & Watson, R. R. (2017). Antioxidants and AIDS. In Nutrients and Foods in Aids (pp. 179-192). CRC Press. https://doi.org/10.1201/9780203745250