Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544

Sergio Martińez-Luis, Lilia Cherigo, Elizabeth Arnold, Carmenza Spadafora, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalNatural Product Communications
Volume7
Issue number2
DOIs
StatePublished - 2012

Keywords

  • Aspergillus sp. strain F1544
  • Fumoquinone
  • L. donovani
  • MCF-7
  • P. falciparum
  • Pseurotins
  • T. cruzi

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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