Antiphospholipid antibodies

Origin, specificity, and mechanism of action

R. L. Brey, Bruce M Coull

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Antiphospholipid antibodies provide a model for immune-mediated thrombosis. Study of the pathophysiological effects of antiphospholipid antibodies has revealed several potential thrombotic mechanisms. Experiments designed to elucidate these mechanisms have used both in vitro and in vivo techniques. Results implicate endothelial anticoagulant dysfunction, abnormalities of prostacyclin, antithrombin III, placental anticoagulant protein, proteins C and S, and complement activation, any of which could lead to thrombosis. In an individual patient, thrombosis may result from a combination of these abnormalities or it may require the presence of other nonimmune-mediated perturbations of the coagulation system.

Original languageEnglish (US)
JournalStroke
Volume23
Issue number2 SUPPL.
StatePublished - 1992
Externally publishedYes

Fingerprint

Antiphospholipid Antibodies
Antibody Specificity
Thrombosis
Anticoagulants
Pregnancy Proteins
Antithrombin III
Complement Activation
Protein S
Epoprostenol
Protein C

Keywords

  • anticoagulants, antiphospholipid antibodies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Antiphospholipid antibodies : Origin, specificity, and mechanism of action. / Brey, R. L.; Coull, Bruce M.

In: Stroke, Vol. 23, No. 2 SUPPL., 1992.

Research output: Contribution to journalArticle

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