Antitumor agents from jatropha macrorhiza (euphorbiaceae) I: Isolation and characterization of jatropham

R. M. Wiedhopf, E. R. Trumbull, J. R. Cole

Research output: Contribution to journalArticle

43 Scopus citations


A new lactam has been isolated from Jatropha macrorhiza (Euphorbiaceae) and has shown tumor‐inhibitory properties against the P‐388 lymphocytic leukemia test system. The compound was identified by means of NMR, UV, IR, rotary dispersion, mass spectrometry, and classical chemical procedures. It has the structure 5‐hydroxy‐4‐methyl‐3‐pyrrolin‐2‐one and has been named jatropham.

Original languageEnglish (US)
Pages (from-to)1206-1207
Number of pages2
JournalJournal of pharmaceutical sciences
Issue number7
StatePublished - Jul 1973



  • 5‐Hydroxy‐4‐methyl‐3‐pyrrolin‐2‐one (jatropham)—isolation from Jatropha macrorhiza, characterization, antitumor activity
  • Antitumor agents—isolation and characterization of jatropham (5‐hydroxy‐4‐methyl‐3‐pyrrolin‐2‐one) from Jatropha macrorhiza
  • Jatropha macrorhiza (Euphorbiaceae)—isolation and characterization of jatropham (5‐hydroxy‐4‐methyl‐3‐pyrrolin‐2‐one), antitumor activity

ASJC Scopus subject areas

  • Pharmaceutical Science

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