@article{5f3d47475fa74e4d86d27134a3b294ce,
title = "Antitumor agents from jatropha macrorhiza (euphorbiaceae) III: Acetylaleuritolic acid",
abstract = "The triterpene acetylaleuritolic acid was isolated from Jatropha macrorhiza (Euphorbiaceae) and showed tumor‐inhibitory properties toward the P‐388 lymphocytic leukemia test system. The compound was identified by means of IR, PMR, and mass spectrometry and by its transformation into the known methyl acetyloleanolate.",
keywords = "Acetylaleuritolic acid—isolated from ethanol extract of roots of Jatropha macrorhiza, antitumor activity evaluated, Antitumor activity—evaluated in acetylaleuritolic acid isolated from ethanol extract of roots of Jatropha macrorhiza, Jatropha macrorhiza—ethanol extract of roots, acetylaleuritolic acid isolated and evaluated for antitumor activity",
author = "Torrance, {S. J.} and Wiedhopf, {R. M.} and Cole, {J. R.}",
note = "Funding Information: Extraction Procedure-The fresh ground roots (90.8 kg) of J. ma- crorhiza were extracted exhaustively in a Lloyd-type extractor with ethanol. The solvent from the ethanol extract was removed in air, and the residue was partitioned between chloroform and water (1:l). After the layers separated, the chloroform was removed in air, resulting in 130.3 g of residue. Isolation of I-The residue from the chloroform phase (100 g) was stirred vigorously with ether (1.4 liters) and filtered. This process provided 7 g of ether-insoluble material and, after removal of the solvent in Dr. Charles T. Mason, Botany Department, University of Arizona, Tucson, Ariz. A reference specimen was deposited in the University of Arizona Herbarium. Tested by the Drug Evaluation Branch, Drug Research and Development, Chemotherapy, National Cancer Institute. An authentic specimen of oleanolic acid was provided by Drug Research and Development, Chemotherapy, National Cancer Institute. Carbon and hydrogen analyses were performed by Chemalytics, Inc., Tempe, Ariz. Mass, PMR, and IR spectra were recorded using a Hewlett-Packard model 5930 spectrometer, a Varian T-60 spectrometer, and a Beckman IR-33, respectively. Optical rotations were obtained on a Rudolph model 70 polarimeter, and melting points were determined on a Kofler hot-stage apparatus and are uncorrected.",
year = "1977",
month = sep,
doi = "10.1002/jps.2600660941",
language = "English (US)",
volume = "66",
pages = "1348--1349",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "9",
}