Aortic arch compliance and idiopathic unilateral vocal fold paralysis

Reza Behkam, Kara E. Roberts, Andrew J. Bierhals, M. Eileen Jacobs, Julia D. Edgar, Randal C. Paniello, Gayle Woodson, Jonathan P. Vande Geest, Julie M. Barkmeier-Kraemer

Research output: Research - peer-reviewArticle

Abstract

Unilateral vocal fold paralysis (UVP) occurs related to recurrent laryngeal nerve (RLN) impairment associated with impaired swallowing, voice production, and breathing functions. The majority of UVP cases occur subsequent to surgical intervention with approximately 12-42% having no known cause for the disease (i.e., idiopathic). Approximately two-thirds of those with UVP exhibit left-sided injury with the average onset at ≥50 yr of age in those diagnosed as idiopathic. Given the association between the RLN and the subclavian and aortic arch vessels, we hypothesized that changes in vascular tissues would result in increased aortic compliance in patients with idiopathic left-sided UVP compared with those without UVP. Gated MRI data enabled aortic arch diameter measures normalized to blood pressure across the cardiac cycles to derive aortic arch compliance. Compliance was compared between individuals with left-sided idiopathic UVP and age- and sex-matched normal controls. Three-way factorial ANOVA test showed that aortic arch compliance (P = 0.02) and aortic arch diameter change in one cardiac cycle (P = 0.04) are significantly higher in patients with idiopathic left-sided UVP compared with the controls. As previously demonstrated by other literature, our finding confirmed that compliance decreases with age (P < 0.0001) in both healthy individuals and patients with idiopathic UVP. Future studies will investigate parameters of aortic compliance change as a potential contributor to the onset of left-sided UVP NEW & NOTEWORTHY Unilateral vocal fold paralysis results from impaired function of the recurrent laryngeal nerve (RLN) impacting breathing, swallowing, and voice production. A large proportion of adults suffering from this disorder have an idiopathic etiology (i.e., unknown cause). The current study determined that individuals diagnosed with left-sided idiopathic vocal fold paralysis exhibited significantly greater compliance than age- and sex-matched controls. These seminal findings suggest a link between aortic arch compliance levels and RLN function..

LanguageEnglish (US)
Pages303-309
Number of pages7
JournalJournal of Applied Physiology
Volume123
Issue number2
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Fingerprint

Vocal Cords
Thoracic Aorta
Paralysis
Compliance
Recurrent Laryngeal Nerve
Deglutition
Respiration
Patient Compliance
Blood Vessels
Analysis of Variance
Blood Pressure
Wounds and Injuries

Keywords

  • Aortic arch compliance
  • Image segmentation
  • Recurrent laryngeal nerve
  • Unilateral vocal fold paralysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Behkam, R., Roberts, K. E., Bierhals, A. J., Jacobs, M. E., Edgar, J. D., Paniello, R. C., ... Barkmeier-Kraemer, J. M. (2017). Aortic arch compliance and idiopathic unilateral vocal fold paralysis. Journal of Applied Physiology, 123(2), 303-309. DOI: 10.1152/japplphysiol.00239.2017

Aortic arch compliance and idiopathic unilateral vocal fold paralysis. / Behkam, Reza; Roberts, Kara E.; Bierhals, Andrew J.; Jacobs, M. Eileen; Edgar, Julia D.; Paniello, Randal C.; Woodson, Gayle; Vande Geest, Jonathan P.; Barkmeier-Kraemer, Julie M.

In: Journal of Applied Physiology, Vol. 123, No. 2, 01.08.2017, p. 303-309.

Research output: Research - peer-reviewArticle

Behkam, R, Roberts, KE, Bierhals, AJ, Jacobs, ME, Edgar, JD, Paniello, RC, Woodson, G, Vande Geest, JP & Barkmeier-Kraemer, JM 2017, 'Aortic arch compliance and idiopathic unilateral vocal fold paralysis' Journal of Applied Physiology, vol 123, no. 2, pp. 303-309. DOI: 10.1152/japplphysiol.00239.2017
Behkam R, Roberts KE, Bierhals AJ, Jacobs ME, Edgar JD, Paniello RC et al. Aortic arch compliance and idiopathic unilateral vocal fold paralysis. Journal of Applied Physiology. 2017 Aug 1;123(2):303-309. Available from, DOI: 10.1152/japplphysiol.00239.2017
Behkam, Reza ; Roberts, Kara E. ; Bierhals, Andrew J. ; Jacobs, M. Eileen ; Edgar, Julia D. ; Paniello, Randal C. ; Woodson, Gayle ; Vande Geest, Jonathan P. ; Barkmeier-Kraemer, Julie M./ Aortic arch compliance and idiopathic unilateral vocal fold paralysis. In: Journal of Applied Physiology. 2017 ; Vol. 123, No. 2. pp. 303-309
@article{b92917aa62d34ac386c33e8f34dc9762,
title = "Aortic arch compliance and idiopathic unilateral vocal fold paralysis",
abstract = "Unilateral vocal fold paralysis (UVP) occurs related to recurrent laryngeal nerve (RLN) impairment associated with impaired swallowing, voice production, and breathing functions. The majority of UVP cases occur subsequent to surgical intervention with approximately 12-42% having no known cause for the disease (i.e., idiopathic). Approximately two-thirds of those with UVP exhibit left-sided injury with the average onset at ≥50 yr of age in those diagnosed as idiopathic. Given the association between the RLN and the subclavian and aortic arch vessels, we hypothesized that changes in vascular tissues would result in increased aortic compliance in patients with idiopathic left-sided UVP compared with those without UVP. Gated MRI data enabled aortic arch diameter measures normalized to blood pressure across the cardiac cycles to derive aortic arch compliance. Compliance was compared between individuals with left-sided idiopathic UVP and age- and sex-matched normal controls. Three-way factorial ANOVA test showed that aortic arch compliance (P = 0.02) and aortic arch diameter change in one cardiac cycle (P = 0.04) are significantly higher in patients with idiopathic left-sided UVP compared with the controls. As previously demonstrated by other literature, our finding confirmed that compliance decreases with age (P < 0.0001) in both healthy individuals and patients with idiopathic UVP. Future studies will investigate parameters of aortic compliance change as a potential contributor to the onset of left-sided UVP NEW & NOTEWORTHY Unilateral vocal fold paralysis results from impaired function of the recurrent laryngeal nerve (RLN) impacting breathing, swallowing, and voice production. A large proportion of adults suffering from this disorder have an idiopathic etiology (i.e., unknown cause). The current study determined that individuals diagnosed with left-sided idiopathic vocal fold paralysis exhibited significantly greater compliance than age- and sex-matched controls. These seminal findings suggest a link between aortic arch compliance levels and RLN function..",
keywords = "Aortic arch compliance, Image segmentation, Recurrent laryngeal nerve, Unilateral vocal fold paralysis",
author = "Reza Behkam and Roberts, {Kara E.} and Bierhals, {Andrew J.} and Jacobs, {M. Eileen} and Edgar, {Julia D.} and Paniello, {Randal C.} and Gayle Woodson and {Vande Geest}, {Jonathan P.} and Barkmeier-Kraemer, {Julie M.}",
year = "2017",
month = "8",
doi = "10.1152/japplphysiol.00239.2017",
volume = "123",
pages = "303--309",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Aortic arch compliance and idiopathic unilateral vocal fold paralysis

AU - Behkam,Reza

AU - Roberts,Kara E.

AU - Bierhals,Andrew J.

AU - Jacobs,M. Eileen

AU - Edgar,Julia D.

AU - Paniello,Randal C.

AU - Woodson,Gayle

AU - Vande Geest,Jonathan P.

AU - Barkmeier-Kraemer,Julie M.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Unilateral vocal fold paralysis (UVP) occurs related to recurrent laryngeal nerve (RLN) impairment associated with impaired swallowing, voice production, and breathing functions. The majority of UVP cases occur subsequent to surgical intervention with approximately 12-42% having no known cause for the disease (i.e., idiopathic). Approximately two-thirds of those with UVP exhibit left-sided injury with the average onset at ≥50 yr of age in those diagnosed as idiopathic. Given the association between the RLN and the subclavian and aortic arch vessels, we hypothesized that changes in vascular tissues would result in increased aortic compliance in patients with idiopathic left-sided UVP compared with those without UVP. Gated MRI data enabled aortic arch diameter measures normalized to blood pressure across the cardiac cycles to derive aortic arch compliance. Compliance was compared between individuals with left-sided idiopathic UVP and age- and sex-matched normal controls. Three-way factorial ANOVA test showed that aortic arch compliance (P = 0.02) and aortic arch diameter change in one cardiac cycle (P = 0.04) are significantly higher in patients with idiopathic left-sided UVP compared with the controls. As previously demonstrated by other literature, our finding confirmed that compliance decreases with age (P < 0.0001) in both healthy individuals and patients with idiopathic UVP. Future studies will investigate parameters of aortic compliance change as a potential contributor to the onset of left-sided UVP NEW & NOTEWORTHY Unilateral vocal fold paralysis results from impaired function of the recurrent laryngeal nerve (RLN) impacting breathing, swallowing, and voice production. A large proportion of adults suffering from this disorder have an idiopathic etiology (i.e., unknown cause). The current study determined that individuals diagnosed with left-sided idiopathic vocal fold paralysis exhibited significantly greater compliance than age- and sex-matched controls. These seminal findings suggest a link between aortic arch compliance levels and RLN function..

AB - Unilateral vocal fold paralysis (UVP) occurs related to recurrent laryngeal nerve (RLN) impairment associated with impaired swallowing, voice production, and breathing functions. The majority of UVP cases occur subsequent to surgical intervention with approximately 12-42% having no known cause for the disease (i.e., idiopathic). Approximately two-thirds of those with UVP exhibit left-sided injury with the average onset at ≥50 yr of age in those diagnosed as idiopathic. Given the association between the RLN and the subclavian and aortic arch vessels, we hypothesized that changes in vascular tissues would result in increased aortic compliance in patients with idiopathic left-sided UVP compared with those without UVP. Gated MRI data enabled aortic arch diameter measures normalized to blood pressure across the cardiac cycles to derive aortic arch compliance. Compliance was compared between individuals with left-sided idiopathic UVP and age- and sex-matched normal controls. Three-way factorial ANOVA test showed that aortic arch compliance (P = 0.02) and aortic arch diameter change in one cardiac cycle (P = 0.04) are significantly higher in patients with idiopathic left-sided UVP compared with the controls. As previously demonstrated by other literature, our finding confirmed that compliance decreases with age (P < 0.0001) in both healthy individuals and patients with idiopathic UVP. Future studies will investigate parameters of aortic compliance change as a potential contributor to the onset of left-sided UVP NEW & NOTEWORTHY Unilateral vocal fold paralysis results from impaired function of the recurrent laryngeal nerve (RLN) impacting breathing, swallowing, and voice production. A large proportion of adults suffering from this disorder have an idiopathic etiology (i.e., unknown cause). The current study determined that individuals diagnosed with left-sided idiopathic vocal fold paralysis exhibited significantly greater compliance than age- and sex-matched controls. These seminal findings suggest a link between aortic arch compliance levels and RLN function..

KW - Aortic arch compliance

KW - Image segmentation

KW - Recurrent laryngeal nerve

KW - Unilateral vocal fold paralysis

UR - http://www.scopus.com/inward/record.url?scp=85026667695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026667695&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00239.2017

DO - 10.1152/japplphysiol.00239.2017

M3 - Article

VL - 123

SP - 303

EP - 309

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -