Apolipoprotein E and intellectual achievement

Richard J. Caselli, Joseph G. Hentz, David Osborne, Neill R. Graff-Radford, Carolyn J. Barbieri, Gene E. Alexander, Geri R. Hall, Eric M. Reiman, John Hardy, Ann M. Saunders

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVES: To determine whether apolipoprotein E (apo E) genotype influences intellectual achievement in cognitively normal individuals. DESIGN: Between 1994 and 1999 we performed apo E testing on 1,000 self-described cognitively normal residents of Maricopa County and detailed neuropsychological testing on a subset of 250. SETTING: Tertiary care academic medical center. PARTICIPANTS: Cognitively normal adults genotyped for apo E. MEASUREMENTS: Measures of intellectual background included years of education and a demographically based estimate of intellectual capacity (demographic intellectual quotient (DIQ)). Measures of intellectual achievement, which included Wechsler Adult Intelligence Scale revised (WAIS-R), information (WAISI), and vocabulary (WAISV) scores, occupational intellectual requirements (OIR), and census-derived estimates of household income, were compared between apo E genetic subgroups while adjusting for intellectual background and demographic variables. RESULTS: WAISI, WAISV, OIR, and income correlated with age, sex, education, and DIQ, but after controlling for these variables there were no clinically significant differences between apo E-e4 homozygotes and noncarriers on any measure. CONCLUSIONS: No clinically significant differences between genotypes were observed for the effects of education and DIQ on WAISI, WAISV, OIR, or income, although a larger sample size would be required to exclude smaller, clinically insignificant differences.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalJournal of the American Geriatrics Society
Volume50
Issue number1
DOIs
StatePublished - 2002

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Apolipoproteins E
Vocabulary
Demography
Genotype
Apolipoprotein E4
Education
Sex Education
Homozygote
Censuses
Tertiary Healthcare
Intelligence
Sample Size

Keywords

  • Aging
  • Alzheimer's disease
  • Apolipoprotein E
  • Intelligence

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Caselli, R. J., Hentz, J. G., Osborne, D., Graff-Radford, N. R., Barbieri, C. J., Alexander, G. E., ... Saunders, A. M. (2002). Apolipoprotein E and intellectual achievement. Journal of the American Geriatrics Society, 50(1), 49-54. https://doi.org/10.1046/j.1532-5415.2002.50007.x

Apolipoprotein E and intellectual achievement. / Caselli, Richard J.; Hentz, Joseph G.; Osborne, David; Graff-Radford, Neill R.; Barbieri, Carolyn J.; Alexander, Gene E.; Hall, Geri R.; Reiman, Eric M.; Hardy, John; Saunders, Ann M.

In: Journal of the American Geriatrics Society, Vol. 50, No. 1, 2002, p. 49-54.

Research output: Contribution to journalArticle

Caselli, RJ, Hentz, JG, Osborne, D, Graff-Radford, NR, Barbieri, CJ, Alexander, GE, Hall, GR, Reiman, EM, Hardy, J & Saunders, AM 2002, 'Apolipoprotein E and intellectual achievement', Journal of the American Geriatrics Society, vol. 50, no. 1, pp. 49-54. https://doi.org/10.1046/j.1532-5415.2002.50007.x
Caselli, Richard J. ; Hentz, Joseph G. ; Osborne, David ; Graff-Radford, Neill R. ; Barbieri, Carolyn J. ; Alexander, Gene E. ; Hall, Geri R. ; Reiman, Eric M. ; Hardy, John ; Saunders, Ann M. / Apolipoprotein E and intellectual achievement. In: Journal of the American Geriatrics Society. 2002 ; Vol. 50, No. 1. pp. 49-54.
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