Appearance and regulation of an antigen associated with limb regeneration in Notophthalmus viridescens

Herman Gordon, Jeremy P. Brockes, Frank Wilson

Research output: Contribution to journalArticle

12 Scopus citations


Previous reports from this laboratory have documented a cellular antigen, 22/18, associated with regeneration of forelimbs in the newt Notophthalmus viridescens (Kintner and Brockes: Nature 308:67–69, 1984; Journal of Embryology and Experimental Morphology 89:37–55, 1985; Brockes: Science 225:1280–1287, 1984; Kintner et al.: Molecular Basis of Neural Development, 1985). The antigen is expressed at various stages of regeneration in several types of cells including Schwann cells and muscle cells. We report here that, in addition to the previous results, the expression of 22/18 occurs very early in the regeneration process and is initially confined to an apparently nonmuscle, non‐neural population of cells. The well‐defined context of the antigen's first appearance has allowed us to investigate the regulation of its expression. In particular, injury is sufficient to elicit the appearance of 22/18. It can appear prior to mitosis and despite denervation. In circumstances where regeneration is inhibited, expression of 22/18 can persist.

Original languageEnglish (US)
Pages (from-to)232-243
Number of pages12
JournalJournal of Experimental Zoology
Issue number3
StatePublished - Sep 1988
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology

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