Application of a Microfluidic-Based Model of a Human Prostate Gland for Cancer Research

Fernando Ivich, Meagan Tran, Shekha Tahsin, Sander B. Frank, Andrew Kraft, Cindy K. Miranti, Yitshak Zohar, Linan Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A Microfluidic-based model of a human prostate gland has been developed featuring a 3D co-culture of epithelial and stromal cells. The model was used to investigate the effects of normal stroma on normal luminal epithelial cell differentiation, and to measure the ability of cancerous epithelium to convert normal stroma to cancer stroma. The ability of PIM1 kinase to induce cancer stroma was also tested in the model. The results demonstrate a promising potential of the model for cancer research applications.

Original languageEnglish (US)
Title of host publicationProceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
PublisherIEEE Computer Society
Pages109-112
Number of pages4
ISBN (Electronic)9781538675786
DOIs
StatePublished - Feb 13 2019
Event12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018 - Waikiki Beach, United States
Duration: Dec 2 2018Dec 5 2018

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Volume2018-December
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Conference12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
CountryUnited States
CityWaikiki Beach
Period12/2/1812/5/18

Keywords

  • Epithelium/stroma coculture
  • Human prostate gland
  • Microfluidics
  • Prostate cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Microbiology (medical)

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