Application of hitherto unexplored macrocyclization strategies in the epothilone series: Novel epothilone analogs by total synthesis

Jon T Njardarson, Kaustav Biswas, Samuel J. Danishefsky

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki-Kishi macrocyclization is described.

Original languageEnglish (US)
Pages (from-to)2759-2761
Number of pages3
JournalChemical Communications
Issue number23
StatePublished - 2002
Externally publishedYes

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Epothilones
Alkenes
Aldehydes
Olefins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Application of hitherto unexplored macrocyclization strategies in the epothilone series : Novel epothilone analogs by total synthesis. / Njardarson, Jon T; Biswas, Kaustav; Danishefsky, Samuel J.

In: Chemical Communications, No. 23, 2002, p. 2759-2761.

Research output: Contribution to journalArticle

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