Application of hitherto unexplored macrocyclization strategies in the epothilone series: Novel epothilone analogs by total synthesis

Jon T Njardarson, Kaustav Biswas, Samuel J. Danishefsky

Research output: Contribution to journalArticle

47 Scopus citations


A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki-Kishi macrocyclization is described.

Original languageEnglish (US)
Pages (from-to)2759-2761
Number of pages3
JournalChemical Communications
Issue number23
Publication statusPublished - 2002
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)

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