Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

Jon T. Njardarson, Kaustav Biswas, Samuel J. Danishefsky

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.

Original languageEnglish (US)
Pages (from-to)2759-2761
Number of pages3
JournalChemical Communications
Volume2
Issue number23
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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