Application of phenolic oxidation chemistry in synthesis: Preparation of the BCE ring system of ryanodine

John L. Wood, Jens K. Graeber, Jón T. Njardarson

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A reaction sequence involving phenolic oxidation followed by singlet oxygen addition was used to assemble a model system containing the trans-fused, bridgehead oxygenated bicyclo[4.3.0] ring system found in the ryanoid group of natural products.

Original languageEnglish (US)
Pages (from-to)8855-8858
Number of pages4
JournalTetrahedron
Volume59
Issue number45
DOIs
StatePublished - Nov 3 2003
Externally publishedYes

Keywords

  • Phenolic oxidation
  • Ryanodine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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