Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions

Jason H. Karnes, Matthew A. Miller, Katie D. White, Katherine C. Konvinse, Rebecca K. Pavlos, Alec J. Redwood, Jonathan G. Peter, Rannakoe Lehloenya, Simon A. Mallal, Elizabeth J. Phillips

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity. Variation in human leukocyte antigen (HLA) genes has emerged as a potential preprescription screening strategy for the prevention of previously unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of immunogenomics and pharmacogenomics and focuses on the effects of immune-specific variation on drug disposition and IM-ADRs. In this review, we present the latest evidence for HLA associations with IM-ADRs, ongoing research into biological mechanisms of IM-ADRs, and the translation of clinical actionable biomarkers for IM-ADRs, with a focus on T cell-mediated ADRs.

Original languageEnglish (US)
Pages (from-to)463-486
Number of pages24
JournalAnnual Review of Pharmacology and Toxicology
Volume59
DOIs
StatePublished - Jan 6 2019

Keywords

  • Adverse drug reaction
  • Human leukocyte antigen
  • Immunopharmacogenomics
  • Pharmacogenomics
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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    Karnes, J. H., Miller, M. A., White, K. D., Konvinse, K. C., Pavlos, R. K., Redwood, A. J., Peter, J. G., Lehloenya, R., Mallal, S. A., & Phillips, E. J. (2019). Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions. Annual Review of Pharmacology and Toxicology, 59, 463-486. https://doi.org/10.1146/annurev-pharmtox-010818-021818