Abstract
This paper investigates the architecture dependence of endothelial cell networks on collective calcium signaling. Upon exogenous histamine stimulation, differential calcium responses are observed in human umbilical vein endothelial cells (IIUVEC) cultured monolayers, plasma lithography patterned hexagon cell networks, and capillary-like structures (CLS) self-organized on matrigel. By systematically modulating the cell-cell interaction with geometrical patterning and the gap-junction intercellular communication with pharmacological reagents, our results reveal the emergent network property of endothelial cells in response to extracellular chemical signals.
| Original language | English (US) |
|---|---|
| Title of host publication | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 428-430 |
| Number of pages | 3 |
| ISBN (Print) | 9781632666246 |
| State | Published - Jan 1 2013 |
| Event | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany Duration: Oct 27 2013 → Oct 31 2013 |
Publication series
| Name | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 |
|---|---|
| Volume | 1 |
Other
| Other | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 |
|---|---|
| Country | Germany |
| City | Freiburg |
| Period | 10/27/13 → 10/31/13 |
Keywords
- Architecture
- Calcium signaling
- Endothelial cells
- Plasma lithography
ASJC Scopus subject areas
- Bioengineering
Fingerprint Dive into the research topics of 'Architecture-dependent collective calcium signaling in microengineered and self-organized endothelial cell networks'. Together they form a unique fingerprint.
Cite this
Sun, J., & Wong, P. K. (2013). Architecture-dependent collective calcium signaling in microengineered and self-organized endothelial cell networks. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 428-430). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1). Chemical and Biological Microsystems Society.