Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules?

Huân M. Ngô, Mei Yang, Keith A Joiner

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The club-shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory granules. We discuss in this article recent data on the cargo, function and biogenesis of rhoptries in two parasitic model systems, Toxoplasma and Plasmodium. Current findings suggest that rhoptries receive products from both biosynthetic and endocytic pathways and, therefore, they are most analogous to secretory lysosomal granules found in mammalian cells.

Original languageEnglish (US)
Pages (from-to)1531-1541
Number of pages11
JournalMolecular Microbiology
Volume52
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Secretory Vesicles
Parasites
Plasmodium
Biosynthetic Pathways
Toxoplasma
Eukaryota
Organelles
Lipids
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology

Cite this

Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules? / Ngô, Huân M.; Yang, Mei; Joiner, Keith A.

In: Molecular Microbiology, Vol. 52, No. 6, 06.2004, p. 1531-1541.

Research output: Contribution to journalArticle

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