Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules?

Huân M. Ngô, Mei Yang, Keith A. Joiner

Research output: Contribution to journalShort survey

57 Scopus citations


The club-shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory granules. We discuss in this article recent data on the cargo, function and biogenesis of rhoptries in two parasitic model systems, Toxoplasma and Plasmodium. Current findings suggest that rhoptries receive products from both biosynthetic and endocytic pathways and, therefore, they are most analogous to secretory lysosomal granules found in mammalian cells.

Original languageEnglish (US)
Pages (from-to)1531-1541
Number of pages11
JournalMolecular Microbiology
Issue number6
StatePublished - Jun 1 2004
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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