Area postrema and sympathetic nervous system effects of vasopressin and angiotensin II

Eileen M. Hasser, J. Thomas Cunningham, Margaret J. Sullivan, Kathleen S. Curtis, Edward H. Blaine, Meredith Hay

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

1. Precise control over the cardiovascular system requires the integration of both neural and humoral signals related to blood volume and blood pressure. Humoral signals interact with neural systems, modulating their control over the efferent mechanisms that ultimately determine the level of pressure and volume. 2. Peptide hormones such as angiotensin (Ang)II and arginine vasopressin (AVP) act through circumventricular organs (CVO) to influence cardiovascular regulation. 3. The area postrema (AP), a CVO in the brainstem, mediates at least some of the central actions of these peptides. Vasopressin appears to act in the AP to cause sympathoinhibition and a shift in baroreflex control of the sympathetic nervous system (SNS) to lower pressures. These effects of AVP and the AP appear to be mediated by α2- adrenoceptor and glutamatergic mechanisms in the nucleus tractus solitarius. 4. In contrast to AVP AngII has effects in the AP to blunt baroreflex control of heart rate and cause sympathoexcitation. The effects of chronic AngII to increase activity of the SNS may be due to AP-dependent activation of neurons in the rostral ventrolateral medulla.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume27
Issue number5-6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Area Postrema
Sympathetic Nervous System
Vasopressins
Angiotensin II
Arginine Vasopressin
Baroreflex
Systems Integration
Pressure
Solitary Nucleus
Peptide Hormones
Cardiovascular System
Blood Volume
Adrenergic Receptors
Brain Stem
Heart Rate
Blood Pressure
Neurons
Peptides

Keywords

  • Angiotensin II
  • Area postrema
  • Arterial blood pressure
  • Baroreflex
  • Hypertension
  • Vasopressin
  • Ventrolateral medulla

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Area postrema and sympathetic nervous system effects of vasopressin and angiotensin II. / Hasser, Eileen M.; Cunningham, J. Thomas; Sullivan, Margaret J.; Curtis, Kathleen S.; Blaine, Edward H.; Hay, Meredith.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 27, No. 5-6, 2000, p. 432-436.

Research output: Contribution to journalArticle

Hasser, Eileen M. ; Cunningham, J. Thomas ; Sullivan, Margaret J. ; Curtis, Kathleen S. ; Blaine, Edward H. ; Hay, Meredith. / Area postrema and sympathetic nervous system effects of vasopressin and angiotensin II. In: Clinical and Experimental Pharmacology and Physiology. 2000 ; Vol. 27, No. 5-6. pp. 432-436.
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