Argentine population genetic structure: Large variance in Amerindian contribution

Michael F. Seldin, Chao Tian, Russell Shigeta, Hugo R. Scherbarth, Gabriel Silva, John W. Belmont, Rick A Kittles, Susana Gamron, Alberto Allevi, Simon A. Palatnik, Alejandro Alvarellos, Sergio Paira, Cesar Caprarulo, Carolina Guillerón, Luis J. Catoggio, Cristina Prigione, Guillermo A. Berbotto, Mercedes A. García, Carlos E. Perandones, Bernardo A. Pons-EstelMarta E. Alarcon-Riquelme

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.

Original languageEnglish (US)
Pages (from-to)455-462
Number of pages8
JournalAmerican Journal of Physical Anthropology
Volume132
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

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Genetic Structures
Population Genetics
population genetics
ancestry
Population
Least-Squares Analysis
Single Nucleotide Polymorphism
Cluster Analysis
least squares
epidemiology
Epidemiology

Keywords

  • Admixture
  • Ancestry informative markers
  • Population stratification

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anthropology

Cite this

Seldin, M. F., Tian, C., Shigeta, R., Scherbarth, H. R., Silva, G., Belmont, J. W., ... Alarcon-Riquelme, M. E. (2007). Argentine population genetic structure: Large variance in Amerindian contribution. American Journal of Physical Anthropology, 132(3), 455-462. https://doi.org/10.1002/ajpa.20534

Argentine population genetic structure : Large variance in Amerindian contribution. / Seldin, Michael F.; Tian, Chao; Shigeta, Russell; Scherbarth, Hugo R.; Silva, Gabriel; Belmont, John W.; Kittles, Rick A; Gamron, Susana; Allevi, Alberto; Palatnik, Simon A.; Alvarellos, Alejandro; Paira, Sergio; Caprarulo, Cesar; Guillerón, Carolina; Catoggio, Luis J.; Prigione, Cristina; Berbotto, Guillermo A.; García, Mercedes A.; Perandones, Carlos E.; Pons-Estel, Bernardo A.; Alarcon-Riquelme, Marta E.

In: American Journal of Physical Anthropology, Vol. 132, No. 3, 03.2007, p. 455-462.

Research output: Contribution to journalArticle

Seldin, MF, Tian, C, Shigeta, R, Scherbarth, HR, Silva, G, Belmont, JW, Kittles, RA, Gamron, S, Allevi, A, Palatnik, SA, Alvarellos, A, Paira, S, Caprarulo, C, Guillerón, C, Catoggio, LJ, Prigione, C, Berbotto, GA, García, MA, Perandones, CE, Pons-Estel, BA & Alarcon-Riquelme, ME 2007, 'Argentine population genetic structure: Large variance in Amerindian contribution', American Journal of Physical Anthropology, vol. 132, no. 3, pp. 455-462. https://doi.org/10.1002/ajpa.20534
Seldin, Michael F. ; Tian, Chao ; Shigeta, Russell ; Scherbarth, Hugo R. ; Silva, Gabriel ; Belmont, John W. ; Kittles, Rick A ; Gamron, Susana ; Allevi, Alberto ; Palatnik, Simon A. ; Alvarellos, Alejandro ; Paira, Sergio ; Caprarulo, Cesar ; Guillerón, Carolina ; Catoggio, Luis J. ; Prigione, Cristina ; Berbotto, Guillermo A. ; García, Mercedes A. ; Perandones, Carlos E. ; Pons-Estel, Bernardo A. ; Alarcon-Riquelme, Marta E. / Argentine population genetic structure : Large variance in Amerindian contribution. In: American Journal of Physical Anthropology. 2007 ; Vol. 132, No. 3. pp. 455-462.
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