Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy Serrano, Holly A. Shill, Douglas G. Walker, Lihfen Lue, Alex E. Roher, Brittany N. Dugger, Chera Maarouf, Alex C. Birdsill, Anthony Intorcia, Megan Saxon-Labelle, Joel Pullen, Alexander Scroggins, Jessica Filon, Sarah Scott, Brittany Hoffman, Angelica Garcia, John N. Caviness & 18 others Joseph G. Hentz, Erika Driver-Dunckley, Sandra A. Jacobson, Kathryn J. Davis, Christine M. Belden, Kathy E. Long, Michael Malek-Ahmadi, Jessica J. Powell, Lisa D. Gale, Lisa R. Nicholson, Richard J. Caselli, Bryan K. Woodruff, Steven Z. Rapscak, Geoffrey L Ahern, Jiong Shi, Anna D. Burke, Eric M. Reiman, Marwan N. Sabbagh

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also directed at subjects with Alzheimer's disease, Parkinson's disease and cancer. The median age at death is 82. Subjects receive standardized general medical, neurological, neuropsychological and movement disorders assessments during life and more than 90% receive full pathological examinations by medically licensed pathologists after death. The Program has been funded through a combination of internal, federal and state of Arizona grants as well as user fees and pharmaceutical industry collaborations. Subsets of the Program are utilized by the US National Institute on Aging Arizona Alzheimer's Disease Core Center and the US National Institute of Neurological Disorders and Stroke National Brain and Tissue Resource for Parkinson's Disease and Related Disorders. Substantial funding has also been received from the Michael J. Fox Foundation for Parkinson's Research. The Program has made rapid autopsy a priority, with a 3.0-hour median post-mortem interval for the entire collection. The median RNA Integrity Number (RIN) for frozen brain and body tissue is 8.9 and 7.4, respectively. More than 2500 tissue requests have been served and currently about 200 are served annually. These requests have been made by more than 400 investigators located in 32 US states and 15 countries. Tissue from the BBDP has contributed to more than 350 publications and more than 200 grant-funded projects.

Original languageEnglish (US)
Pages (from-to)354-389
Number of pages36
JournalNeuropathology
Volume35
Issue number4
DOIs
StatePublished - Aug 1 2015

Fingerprint

Neurodegenerative Diseases
Brain
Organized Financing
Parkinson Disease
Alzheimer Disease
National Institute on Aging (U.S.)
National Institute of Neurological Disorders and Stroke
Fees and Charges
Retirement
Movement Disorders
Drug Industry
Solar System
Nervous System Diseases
Publications
Autopsy
Healthy Volunteers
Research Personnel
RNA
Health
Research

Keywords

  • Aging
  • Alzheimer's disease
  • Autopsy
  • Biobank
  • Biospecimen
  • Brain bank
  • Cancer
  • Freeze-thaw
  • Parkinson's disease
  • Pathology
  • Post-mortem interval
  • RNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Beach, T. G., Adler, C. H., Sue, L. I., Serrano, G., Shill, H. A., Walker, D. G., ... Sabbagh, M. N. (2015). Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program. Neuropathology, 35(4), 354-389. https://doi.org/10.1111/neup.12189

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program. / Beach, Thomas G.; Adler, Charles H.; Sue, Lucia I.; Serrano, Geidy; Shill, Holly A.; Walker, Douglas G.; Lue, Lihfen; Roher, Alex E.; Dugger, Brittany N.; Maarouf, Chera; Birdsill, Alex C.; Intorcia, Anthony; Saxon-Labelle, Megan; Pullen, Joel; Scroggins, Alexander; Filon, Jessica; Scott, Sarah; Hoffman, Brittany; Garcia, Angelica; Caviness, John N.; Hentz, Joseph G.; Driver-Dunckley, Erika; Jacobson, Sandra A.; Davis, Kathryn J.; Belden, Christine M.; Long, Kathy E.; Malek-Ahmadi, Michael; Powell, Jessica J.; Gale, Lisa D.; Nicholson, Lisa R.; Caselli, Richard J.; Woodruff, Bryan K.; Rapscak, Steven Z.; Ahern, Geoffrey L; Shi, Jiong; Burke, Anna D.; Reiman, Eric M.; Sabbagh, Marwan N.

In: Neuropathology, Vol. 35, No. 4, 01.08.2015, p. 354-389.

Research output: Contribution to journalArticle

Beach, TG, Adler, CH, Sue, LI, Serrano, G, Shill, HA, Walker, DG, Lue, L, Roher, AE, Dugger, BN, Maarouf, C, Birdsill, AC, Intorcia, A, Saxon-Labelle, M, Pullen, J, Scroggins, A, Filon, J, Scott, S, Hoffman, B, Garcia, A, Caviness, JN, Hentz, JG, Driver-Dunckley, E, Jacobson, SA, Davis, KJ, Belden, CM, Long, KE, Malek-Ahmadi, M, Powell, JJ, Gale, LD, Nicholson, LR, Caselli, RJ, Woodruff, BK, Rapscak, SZ, Ahern, GL, Shi, J, Burke, AD, Reiman, EM & Sabbagh, MN 2015, 'Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program', Neuropathology, vol. 35, no. 4, pp. 354-389. https://doi.org/10.1111/neup.12189
Beach TG, Adler CH, Sue LI, Serrano G, Shill HA, Walker DG et al. Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program. Neuropathology. 2015 Aug 1;35(4):354-389. https://doi.org/10.1111/neup.12189
Beach, Thomas G. ; Adler, Charles H. ; Sue, Lucia I. ; Serrano, Geidy ; Shill, Holly A. ; Walker, Douglas G. ; Lue, Lihfen ; Roher, Alex E. ; Dugger, Brittany N. ; Maarouf, Chera ; Birdsill, Alex C. ; Intorcia, Anthony ; Saxon-Labelle, Megan ; Pullen, Joel ; Scroggins, Alexander ; Filon, Jessica ; Scott, Sarah ; Hoffman, Brittany ; Garcia, Angelica ; Caviness, John N. ; Hentz, Joseph G. ; Driver-Dunckley, Erika ; Jacobson, Sandra A. ; Davis, Kathryn J. ; Belden, Christine M. ; Long, Kathy E. ; Malek-Ahmadi, Michael ; Powell, Jessica J. ; Gale, Lisa D. ; Nicholson, Lisa R. ; Caselli, Richard J. ; Woodruff, Bryan K. ; Rapscak, Steven Z. ; Ahern, Geoffrey L ; Shi, Jiong ; Burke, Anna D. ; Reiman, Eric M. ; Sabbagh, Marwan N. / Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program. In: Neuropathology. 2015 ; Vol. 35, No. 4. pp. 354-389.
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