Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma

Anjan Misra, Malgorzata Pellarin, Janice Nigro, Ivan Smirnov, Dan Moore, Kathleen R. Lamborn, Daniel Pinkel, Donna G. Albertson, Burt G. Feuerstein

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10 loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes 7 or 10. The significance of these genetic groups to therapeutics needs further study.

Original languageEnglish (US)
Pages (from-to)2907-2918
Number of pages12
JournalClinical Cancer Research
Volume11
Issue number8
DOIs
StatePublished - Apr 15 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Misra, A., Pellarin, M., Nigro, J., Smirnov, I., Moore, D., Lamborn, K. R., Pinkel, D., Albertson, D. G., & Feuerstein, B. G. (2005). Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma. Clinical Cancer Research, 11(8), 2907-2918. https://doi.org/10.1158/1078-0432.CCR-04-0708