Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: Results from the North American Multidisciplinary Study

Frank I. Marcus, Wojciech Zareba, Hugh Calkins, Jeffrey A. Towbin, Cristina Basso, David A. Bluemke, N. A Mark Estes, Michael H. Picard, Danita Sanborn, Gaetano Thiene, Thomas Wichter, David Cannom, David J. Wilber, Melvin Scheinman, Henry Duff, James Daubert, Mario Talajic, Andrew Krahn, Michael Sweeney, Hasan GaranScott Sakaguchi, Bruce B. Lerman, Charles Kerr, Jack Kron, Jonathan S. Steinberg, Duane L Sherrill, Kathleen Gear, Mary Brown, Patricia Severski, Slava Polonsky, Scott McNitt

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background: Prior reports on patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) focused on individuals with advanced forms of the disease. Data on the diagnostic performance of various testing modalities in newly identified individuals suspected of having ARVC/D are limited. Objective: The purpose of the Multidisciplinary Study of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia was to study the clinical characteristics and diagnostic evaluation of a large group of patients newly identified with ARVC/D. Methods: A total of 108 newly diagnosed patients with suspected ARVC/D were prospectively enrolled in the United States and Canada. The patients underwent noninvasive and invasive tests using standardized protocols that initially were interpreted by the enrolling center and adjudicated by blind analysis in six core laboratories. Patients were followed for a mean of 27 ± 16 months (range 0.2-63 months). Results: The clinical profile of these newly diagnosed patients differs from the profile of reported patients with more advanced disease. There was considerable difference in the initial and final classification of the presence of ARVC/D after the diagnostic tests were evaluated by the core laboratories. Final clinical diagnosis was 73 affected, 28 borderline, and 7 unaffected. Individual tests agreed with the final diagnosis in 50% to 70% of the 73 patients with a final classification of affected. Conclusion: The clinical profile of 108 newly diagnosed probands with suspected ARVC/D indicates that a combination of diagnostic tests is needed to evaluate the presence of right ventricular structural, functional, and electrical abnormalities. Echocardiography, right ventricular angiography, signal-averaged ECG, and Holter monitoring provide optimal clinical evaluation of patients suspected of ARVC/D.

Original languageEnglish (US)
Pages (from-to)984-992
Number of pages9
JournalHeart Rhythm
Volume6
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

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Arrhythmogenic Right Ventricular Dysplasia
Routine Diagnostic Tests
Ambulatory Electrocardiography
Canada
Echocardiography
Angiography
Electrocardiography

Keywords

  • Cardiomyopathy
  • Genetics
  • Implantable cardioverter-defibrillator
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation : Results from the North American Multidisciplinary Study. / Marcus, Frank I.; Zareba, Wojciech; Calkins, Hugh; Towbin, Jeffrey A.; Basso, Cristina; Bluemke, David A.; Estes, N. A Mark; Picard, Michael H.; Sanborn, Danita; Thiene, Gaetano; Wichter, Thomas; Cannom, David; Wilber, David J.; Scheinman, Melvin; Duff, Henry; Daubert, James; Talajic, Mario; Krahn, Andrew; Sweeney, Michael; Garan, Hasan; Sakaguchi, Scott; Lerman, Bruce B.; Kerr, Charles; Kron, Jack; Steinberg, Jonathan S.; Sherrill, Duane L; Gear, Kathleen; Brown, Mary; Severski, Patricia; Polonsky, Slava; McNitt, Scott.

In: Heart Rhythm, Vol. 6, No. 7, 07.2009, p. 984-992.

Research output: Contribution to journalArticle

Marcus, FI, Zareba, W, Calkins, H, Towbin, JA, Basso, C, Bluemke, DA, Estes, NAM, Picard, MH, Sanborn, D, Thiene, G, Wichter, T, Cannom, D, Wilber, DJ, Scheinman, M, Duff, H, Daubert, J, Talajic, M, Krahn, A, Sweeney, M, Garan, H, Sakaguchi, S, Lerman, BB, Kerr, C, Kron, J, Steinberg, JS, Sherrill, DL, Gear, K, Brown, M, Severski, P, Polonsky, S & McNitt, S 2009, 'Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: Results from the North American Multidisciplinary Study', Heart Rhythm, vol. 6, no. 7, pp. 984-992. https://doi.org/10.1016/j.hrthm.2009.03.013
Marcus, Frank I. ; Zareba, Wojciech ; Calkins, Hugh ; Towbin, Jeffrey A. ; Basso, Cristina ; Bluemke, David A. ; Estes, N. A Mark ; Picard, Michael H. ; Sanborn, Danita ; Thiene, Gaetano ; Wichter, Thomas ; Cannom, David ; Wilber, David J. ; Scheinman, Melvin ; Duff, Henry ; Daubert, James ; Talajic, Mario ; Krahn, Andrew ; Sweeney, Michael ; Garan, Hasan ; Sakaguchi, Scott ; Lerman, Bruce B. ; Kerr, Charles ; Kron, Jack ; Steinberg, Jonathan S. ; Sherrill, Duane L ; Gear, Kathleen ; Brown, Mary ; Severski, Patricia ; Polonsky, Slava ; McNitt, Scott. / Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation : Results from the North American Multidisciplinary Study. In: Heart Rhythm. 2009 ; Vol. 6, No. 7. pp. 984-992.
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T2 - Results from the North American Multidisciplinary Study

AU - Marcus, Frank I.

AU - Zareba, Wojciech

AU - Calkins, Hugh

AU - Towbin, Jeffrey A.

AU - Basso, Cristina

AU - Bluemke, David A.

AU - Estes, N. A Mark

AU - Picard, Michael H.

AU - Sanborn, Danita

AU - Thiene, Gaetano

AU - Wichter, Thomas

AU - Cannom, David

AU - Wilber, David J.

AU - Scheinman, Melvin

AU - Duff, Henry

AU - Daubert, James

AU - Talajic, Mario

AU - Krahn, Andrew

AU - Sweeney, Michael

AU - Garan, Hasan

AU - Sakaguchi, Scott

AU - Lerman, Bruce B.

AU - Kerr, Charles

AU - Kron, Jack

AU - Steinberg, Jonathan S.

AU - Sherrill, Duane L

AU - Gear, Kathleen

AU - Brown, Mary

AU - Severski, Patricia

AU - Polonsky, Slava

AU - McNitt, Scott

PY - 2009/7

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N2 - Background: Prior reports on patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) focused on individuals with advanced forms of the disease. Data on the diagnostic performance of various testing modalities in newly identified individuals suspected of having ARVC/D are limited. Objective: The purpose of the Multidisciplinary Study of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia was to study the clinical characteristics and diagnostic evaluation of a large group of patients newly identified with ARVC/D. Methods: A total of 108 newly diagnosed patients with suspected ARVC/D were prospectively enrolled in the United States and Canada. The patients underwent noninvasive and invasive tests using standardized protocols that initially were interpreted by the enrolling center and adjudicated by blind analysis in six core laboratories. Patients were followed for a mean of 27 ± 16 months (range 0.2-63 months). Results: The clinical profile of these newly diagnosed patients differs from the profile of reported patients with more advanced disease. There was considerable difference in the initial and final classification of the presence of ARVC/D after the diagnostic tests were evaluated by the core laboratories. Final clinical diagnosis was 73 affected, 28 borderline, and 7 unaffected. Individual tests agreed with the final diagnosis in 50% to 70% of the 73 patients with a final classification of affected. Conclusion: The clinical profile of 108 newly diagnosed probands with suspected ARVC/D indicates that a combination of diagnostic tests is needed to evaluate the presence of right ventricular structural, functional, and electrical abnormalities. Echocardiography, right ventricular angiography, signal-averaged ECG, and Holter monitoring provide optimal clinical evaluation of patients suspected of ARVC/D.

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KW - Cardiomyopathy

KW - Genetics

KW - Implantable cardioverter-defibrillator

KW - Ventricular tachycardia

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