Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism

Brenda Gamboa-Loira, César Hernández-Alcaraz, A Jay Gandolfi, Mariano E. Cebrián, Ana Burguete-García, Angélica García-Martínez, Lizbeth López-Carrillo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Nutrients and genetic polymorphisms participating in one-carbon metabolism may explain interindividual differences in inorganic arsenic (iAs) methylation capacity, which in turn may account for variations in susceptibility to iAs-induced diseases. Objectives: 1) To evaluate the association between polymorphisms in five one-carbon metabolism genes (FOLH1 c.223 T > C, MTHFD1 c.1958 G > A, MTHFR c.665 C > T, MTR c.2756 A > G, and MTRR c.66 A > G) and iAs methylation capacity; 2) To assess if previously reported associations between nutrient intake and iAs methylation capacity are modified by those polymorphisms. Methods: Women (n = 1027) exposed to iAs in Northern Mexico were interviewed. Blood and urine samples were collected. Nutrient dietary intake was estimated using a validated food frequency questionnaire. iAs methylation capacity was calculated from urinary iAs species (iAs, monomethylarsonic acid [MMA] and dimethylarsinic acid [DMA]) measured by high performance liquid chromatography (HPLC-ICP-MS). One polymorphism in each of the five genes evaluated was genotyped by allelic discrimination. Multivariable linear regression models were used to evaluate if genetic polymorphisms modified the associations between iAs methylation capacity parameters and nutrient intake. Results: The median (min-max) concentration of total arsenic (TAs) was 20.2 (1.3–2776.0) µg/g creatinine in the study population. Significant interactions for iAs metabolism were only found with FOLH1 c.223 T > C polymorphism and vitamin B12 intake, so that CT and CC genotype carriers had significantly lower %iAs, and higher DMA/iAs with an increased vitamin B12 intake, as compared to carriers of wild-type TT. Conclusion: Differences in dietary nutrient intake and genetic variants in one-carbon metabolism may jointly influence iAs methylation capacity. Confirmation of these interactions in other populations is warranted.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalEnvironmental Research
Volume164
DOIs
StatePublished - Jul 1 2018

Fingerprint

Methylation
methylation
Arsenic
Genetic Polymorphisms
Polymorphism
Metabolism
Nutrients
arsenic
polymorphism
Carbon
metabolism
Food
nutrient
carbon
Cacodylic Acid
Vitamin B 12
vitamin
Linear Models
High Pressure Liquid Chromatography
Genes

Keywords

  • Arsenic metabolism
  • Inorganic arsenic
  • Micronutrients
  • Northern Mexico
  • Polymorphisms

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Gamboa-Loira, B., Hernández-Alcaraz, C., Gandolfi, A. J., Cebrián, M. E., Burguete-García, A., García-Martínez, A., & López-Carrillo, L. (2018). Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism. Environmental Research, 164, 18-23. https://doi.org/10.1016/j.envres.2018.01.050

Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism. / Gamboa-Loira, Brenda; Hernández-Alcaraz, César; Gandolfi, A Jay; Cebrián, Mariano E.; Burguete-García, Ana; García-Martínez, Angélica; López-Carrillo, Lizbeth.

In: Environmental Research, Vol. 164, 01.07.2018, p. 18-23.

Research output: Contribution to journalArticle

Gamboa-Loira, B, Hernández-Alcaraz, C, Gandolfi, AJ, Cebrián, ME, Burguete-García, A, García-Martínez, A & López-Carrillo, L 2018, 'Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism', Environmental Research, vol. 164, pp. 18-23. https://doi.org/10.1016/j.envres.2018.01.050
Gamboa-Loira, Brenda ; Hernández-Alcaraz, César ; Gandolfi, A Jay ; Cebrián, Mariano E. ; Burguete-García, Ana ; García-Martínez, Angélica ; López-Carrillo, Lizbeth. / Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism. In: Environmental Research. 2018 ; Vol. 164. pp. 18-23.
@article{e6485ee174b147fea89a450a063e2087,
title = "Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism",
abstract = "Background: Nutrients and genetic polymorphisms participating in one-carbon metabolism may explain interindividual differences in inorganic arsenic (iAs) methylation capacity, which in turn may account for variations in susceptibility to iAs-induced diseases. Objectives: 1) To evaluate the association between polymorphisms in five one-carbon metabolism genes (FOLH1 c.223 T > C, MTHFD1 c.1958 G > A, MTHFR c.665 C > T, MTR c.2756 A > G, and MTRR c.66 A > G) and iAs methylation capacity; 2) To assess if previously reported associations between nutrient intake and iAs methylation capacity are modified by those polymorphisms. Methods: Women (n = 1027) exposed to iAs in Northern Mexico were interviewed. Blood and urine samples were collected. Nutrient dietary intake was estimated using a validated food frequency questionnaire. iAs methylation capacity was calculated from urinary iAs species (iAs, monomethylarsonic acid [MMA] and dimethylarsinic acid [DMA]) measured by high performance liquid chromatography (HPLC-ICP-MS). One polymorphism in each of the five genes evaluated was genotyped by allelic discrimination. Multivariable linear regression models were used to evaluate if genetic polymorphisms modified the associations between iAs methylation capacity parameters and nutrient intake. Results: The median (min-max) concentration of total arsenic (TAs) was 20.2 (1.3–2776.0) µg/g creatinine in the study population. Significant interactions for iAs metabolism were only found with FOLH1 c.223 T > C polymorphism and vitamin B12 intake, so that CT and CC genotype carriers had significantly lower {\%}iAs, and higher DMA/iAs with an increased vitamin B12 intake, as compared to carriers of wild-type TT. Conclusion: Differences in dietary nutrient intake and genetic variants in one-carbon metabolism may jointly influence iAs methylation capacity. Confirmation of these interactions in other populations is warranted.",
keywords = "Arsenic metabolism, Inorganic arsenic, Micronutrients, Northern Mexico, Polymorphisms",
author = "Brenda Gamboa-Loira and C{\'e}sar Hern{\'a}ndez-Alcaraz and Gandolfi, {A Jay} and Cebri{\'a}n, {Mariano E.} and Ana Burguete-Garc{\'i}a and Ang{\'e}lica Garc{\'i}a-Mart{\'i}nez and Lizbeth L{\'o}pez-Carrillo",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.envres.2018.01.050",
language = "English (US)",
volume = "164",
pages = "18--23",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism

AU - Gamboa-Loira, Brenda

AU - Hernández-Alcaraz, César

AU - Gandolfi, A Jay

AU - Cebrián, Mariano E.

AU - Burguete-García, Ana

AU - García-Martínez, Angélica

AU - López-Carrillo, Lizbeth

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Nutrients and genetic polymorphisms participating in one-carbon metabolism may explain interindividual differences in inorganic arsenic (iAs) methylation capacity, which in turn may account for variations in susceptibility to iAs-induced diseases. Objectives: 1) To evaluate the association between polymorphisms in five one-carbon metabolism genes (FOLH1 c.223 T > C, MTHFD1 c.1958 G > A, MTHFR c.665 C > T, MTR c.2756 A > G, and MTRR c.66 A > G) and iAs methylation capacity; 2) To assess if previously reported associations between nutrient intake and iAs methylation capacity are modified by those polymorphisms. Methods: Women (n = 1027) exposed to iAs in Northern Mexico were interviewed. Blood and urine samples were collected. Nutrient dietary intake was estimated using a validated food frequency questionnaire. iAs methylation capacity was calculated from urinary iAs species (iAs, monomethylarsonic acid [MMA] and dimethylarsinic acid [DMA]) measured by high performance liquid chromatography (HPLC-ICP-MS). One polymorphism in each of the five genes evaluated was genotyped by allelic discrimination. Multivariable linear regression models were used to evaluate if genetic polymorphisms modified the associations between iAs methylation capacity parameters and nutrient intake. Results: The median (min-max) concentration of total arsenic (TAs) was 20.2 (1.3–2776.0) µg/g creatinine in the study population. Significant interactions for iAs metabolism were only found with FOLH1 c.223 T > C polymorphism and vitamin B12 intake, so that CT and CC genotype carriers had significantly lower %iAs, and higher DMA/iAs with an increased vitamin B12 intake, as compared to carriers of wild-type TT. Conclusion: Differences in dietary nutrient intake and genetic variants in one-carbon metabolism may jointly influence iAs methylation capacity. Confirmation of these interactions in other populations is warranted.

AB - Background: Nutrients and genetic polymorphisms participating in one-carbon metabolism may explain interindividual differences in inorganic arsenic (iAs) methylation capacity, which in turn may account for variations in susceptibility to iAs-induced diseases. Objectives: 1) To evaluate the association between polymorphisms in five one-carbon metabolism genes (FOLH1 c.223 T > C, MTHFD1 c.1958 G > A, MTHFR c.665 C > T, MTR c.2756 A > G, and MTRR c.66 A > G) and iAs methylation capacity; 2) To assess if previously reported associations between nutrient intake and iAs methylation capacity are modified by those polymorphisms. Methods: Women (n = 1027) exposed to iAs in Northern Mexico were interviewed. Blood and urine samples were collected. Nutrient dietary intake was estimated using a validated food frequency questionnaire. iAs methylation capacity was calculated from urinary iAs species (iAs, monomethylarsonic acid [MMA] and dimethylarsinic acid [DMA]) measured by high performance liquid chromatography (HPLC-ICP-MS). One polymorphism in each of the five genes evaluated was genotyped by allelic discrimination. Multivariable linear regression models were used to evaluate if genetic polymorphisms modified the associations between iAs methylation capacity parameters and nutrient intake. Results: The median (min-max) concentration of total arsenic (TAs) was 20.2 (1.3–2776.0) µg/g creatinine in the study population. Significant interactions for iAs metabolism were only found with FOLH1 c.223 T > C polymorphism and vitamin B12 intake, so that CT and CC genotype carriers had significantly lower %iAs, and higher DMA/iAs with an increased vitamin B12 intake, as compared to carriers of wild-type TT. Conclusion: Differences in dietary nutrient intake and genetic variants in one-carbon metabolism may jointly influence iAs methylation capacity. Confirmation of these interactions in other populations is warranted.

KW - Arsenic metabolism

KW - Inorganic arsenic

KW - Micronutrients

KW - Northern Mexico

KW - Polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=85042289830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042289830&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2018.01.050

DO - 10.1016/j.envres.2018.01.050

M3 - Article

VL - 164

SP - 18

EP - 23

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -