Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus

E. M. Kithsiri Wijeratne, Leslie Gunatilaka, David G I Kingston, R. Curtis Haltiwanger, Drake S. Eggleston

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The structure of artabotrine, an unprecedented bioactive N-methoxylated alkaloid from Artabotrys zeylanicus, has been deduced as N-methoxynorcepharadione A (1) from spectral data and single crystal X-ray analysis. The known oxoaporphine alkaloid, atherospennidine (2), was also isolated and shown to be active in a mechanism-based yeast bioassay.

Original languageEnglish (US)
Pages (from-to)7877-7882
Number of pages6
JournalTetrahedron
Volume51
Issue number29
DOIs
StatePublished - Jul 17 1995
Externally publishedYes

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Annonaceae
Alkaloids
Bioassay
X ray analysis
Biological Assay
Yeast
Yeasts
X-Rays
Single crystals
artabotrine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Kithsiri Wijeratne, E. M., Gunatilaka, L., Kingston, D. G. I., Curtis Haltiwanger, R., & Eggleston, D. S. (1995). Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus. Tetrahedron, 51(29), 7877-7882. https://doi.org/10.1016/0040-4020(95)00422-5

Artabotrine : A novel bioactive alkaloid from Artabotrys zeylanicus. / Kithsiri Wijeratne, E. M.; Gunatilaka, Leslie; Kingston, David G I; Curtis Haltiwanger, R.; Eggleston, Drake S.

In: Tetrahedron, Vol. 51, No. 29, 17.07.1995, p. 7877-7882.

Research output: Contribution to journalArticle

Kithsiri Wijeratne, EM, Gunatilaka, L, Kingston, DGI, Curtis Haltiwanger, R & Eggleston, DS 1995, 'Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus', Tetrahedron, vol. 51, no. 29, pp. 7877-7882. https://doi.org/10.1016/0040-4020(95)00422-5
Kithsiri Wijeratne EM, Gunatilaka L, Kingston DGI, Curtis Haltiwanger R, Eggleston DS. Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus. Tetrahedron. 1995 Jul 17;51(29):7877-7882. https://doi.org/10.1016/0040-4020(95)00422-5
Kithsiri Wijeratne, E. M. ; Gunatilaka, Leslie ; Kingston, David G I ; Curtis Haltiwanger, R. ; Eggleston, Drake S. / Artabotrine : A novel bioactive alkaloid from Artabotrys zeylanicus. In: Tetrahedron. 1995 ; Vol. 51, No. 29. pp. 7877-7882.
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