Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus

E. M. Kithsiri Wijeratne, A. A. Leslie Gunatilaka, David G.I. Kingston, R. Curtis Haltiwanger, Drake S. Eggleston

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The structure of artabotrine, an unprecedented bioactive N-methoxylated alkaloid from Artabotrys zeylanicus, has been deduced as N-methoxynorcepharadione A (1) from spectral data and single crystal X-ray analysis. The known oxoaporphine alkaloid, atherospennidine (2), was also isolated and shown to be active in a mechanism-based yeast bioassay.

Original languageEnglish (US)
Pages (from-to)7877-7882
Number of pages6
JournalTetrahedron
Volume51
Issue number29
DOIs
StatePublished - Jul 17 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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