Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity

N. Kubesch, A. De Nazelle, S. Guerra, D. Westerdahl, D. Martinez, L. Bouso, G. Carrasco-Turigas, B. Hoffmann, M. J. Nieuwenhuijsen

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Background: Short-term exposure to traffic-related air pollution (TRAP) has been associated with adverse cardiovascular outcomes. Physical activity (PA) in polluted air may increase pollutant uptake and increase these effects. Methods: Crossover real-world exposure study in 28 healthy participants comparing systolic (SBP) and diastolic blood pressure (DBP) responses to four different exposure scenarios: 2 h exposure in high or low-TRAP environment, each at rest and combined with intermittent moderate PA consisting of 15 min intervals alternating rest and cycling on a stationary bicycle. Data was analyzed using mixed effect models for repeated measures. Results: Exposure to high TRAP was associated with higher DBP (1.1 mm/Hg, p0.002) post-exposure, irrespective of exercise status. Ultrafine particles (UFP) increased DBP post-exposure (0.9 mm/Hg, p0.004). Interquartile increases in black carbon (BC), fine particulate matter (PM10 and PMcoarse), UFP, and nitric oxides (NOx) were associated with statistically significantly higher SBP post-exposure (1.2, 1.0, 1.1, and 1.1 mm/Hg, respectively). Intermittent PA compared with rest was associated with lower SBP post-exposure (-2.4 mm/Hg, p<0.001). PA lowered SBP more after exposure to the low-TRAP site (-2.3 mm/Hg) compared with the high-TRAP site (-1.6 mm/Hg). We only found evidence of an interaction between PA and both PM10 and PMcoarse, increasing SBP. Conclusion: Both SBP and DBP increase after exposure to TRAP. Intermittent PA attenuates the TRAP-related increases in SBP, with the exception of PM10 and PMcoarse, which potentiate these increases. We showed that in low-TRAP environments intermittent PA has stronger beneficial effects on SBP than in high-TRAP environments.

Original languageEnglish (US)
Pages (from-to)548-557
Number of pages10
JournalEuropean Journal of Preventive Cardiology
Volume22
Issue number5
DOIs
StatePublished - May 15 2015

Keywords

  • Blood pressure
  • cycling
  • particulate matter
  • physical activity
  • short-term exposure
  • traffic-related air pollution

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

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