Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity

N. Kubesch, A. De Nazelle, S. Guerra, D. Westerdahl, D. Martinez, L. Bouso, G. Carrasco-Turigas, B. Hoffmann, M. J. Nieuwenhuijsen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Short-term exposure to traffic-related air pollution (TRAP) has been associated with adverse cardiovascular outcomes. Physical activity (PA) in polluted air may increase pollutant uptake and increase these effects. Methods: Crossover real-world exposure study in 28 healthy participants comparing systolic (SBP) and diastolic blood pressure (DBP) responses to four different exposure scenarios: 2 h exposure in high or low-TRAP environment, each at rest and combined with intermittent moderate PA consisting of 15 min intervals alternating rest and cycling on a stationary bicycle. Data was analyzed using mixed effect models for repeated measures. Results: Exposure to high TRAP was associated with higher DBP (1.1 mm/Hg, p0.002) post-exposure, irrespective of exercise status. Ultrafine particles (UFP) increased DBP post-exposure (0.9 mm/Hg, p0.004). Interquartile increases in black carbon (BC), fine particulate matter (PM10 and PMcoarse), UFP, and nitric oxides (NOx) were associated with statistically significantly higher SBP post-exposure (1.2, 1.0, 1.1, and 1.1 mm/Hg, respectively). Intermittent PA compared with rest was associated with lower SBP post-exposure (-2.4 mm/Hg, p<0.001). PA lowered SBP more after exposure to the low-TRAP site (-2.3 mm/Hg) compared with the high-TRAP site (-1.6 mm/Hg). We only found evidence of an interaction between PA and both PM10 and PMcoarse, increasing SBP. Conclusion: Both SBP and DBP increase after exposure to TRAP. Intermittent PA attenuates the TRAP-related increases in SBP, with the exception of PM10 and PMcoarse, which potentiate these increases. We showed that in low-TRAP environments intermittent PA has stronger beneficial effects on SBP than in high-TRAP environments.

Original languageEnglish (US)
Pages (from-to)548-557
Number of pages10
JournalEuropean Journal of Preventive Cardiology
Volume22
Issue number5
DOIs
StatePublished - May 15 2015

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Air Pollution
Arterial Pressure
Exercise
Blood Pressure
Soot
Particulate Matter
Healthy Volunteers
Nitric Oxide
Air
Hypertension

Keywords

  • Blood pressure
  • cycling
  • particulate matter
  • physical activity
  • short-term exposure
  • traffic-related air pollution

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

Cite this

Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity. / Kubesch, N.; De Nazelle, A.; Guerra, S.; Westerdahl, D.; Martinez, D.; Bouso, L.; Carrasco-Turigas, G.; Hoffmann, B.; Nieuwenhuijsen, M. J.

In: European Journal of Preventive Cardiology, Vol. 22, No. 5, 15.05.2015, p. 548-557.

Research output: Contribution to journalArticle

Kubesch, N, De Nazelle, A, Guerra, S, Westerdahl, D, Martinez, D, Bouso, L, Carrasco-Turigas, G, Hoffmann, B & Nieuwenhuijsen, MJ 2015, 'Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity', European Journal of Preventive Cardiology, vol. 22, no. 5, pp. 548-557. https://doi.org/10.1177/2047487314555602
Kubesch, N. ; De Nazelle, A. ; Guerra, S. ; Westerdahl, D. ; Martinez, D. ; Bouso, L. ; Carrasco-Turigas, G. ; Hoffmann, B. ; Nieuwenhuijsen, M. J. / Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity. In: European Journal of Preventive Cardiology. 2015 ; Vol. 22, No. 5. pp. 548-557.
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AU - Kubesch, N.

AU - De Nazelle, A.

AU - Guerra, S.

AU - Westerdahl, D.

AU - Martinez, D.

AU - Bouso, L.

AU - Carrasco-Turigas, G.

AU - Hoffmann, B.

AU - Nieuwenhuijsen, M. J.

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N2 - Background: Short-term exposure to traffic-related air pollution (TRAP) has been associated with adverse cardiovascular outcomes. Physical activity (PA) in polluted air may increase pollutant uptake and increase these effects. Methods: Crossover real-world exposure study in 28 healthy participants comparing systolic (SBP) and diastolic blood pressure (DBP) responses to four different exposure scenarios: 2 h exposure in high or low-TRAP environment, each at rest and combined with intermittent moderate PA consisting of 15 min intervals alternating rest and cycling on a stationary bicycle. Data was analyzed using mixed effect models for repeated measures. Results: Exposure to high TRAP was associated with higher DBP (1.1 mm/Hg, p0.002) post-exposure, irrespective of exercise status. Ultrafine particles (UFP) increased DBP post-exposure (0.9 mm/Hg, p0.004). Interquartile increases in black carbon (BC), fine particulate matter (PM10 and PMcoarse), UFP, and nitric oxides (NOx) were associated with statistically significantly higher SBP post-exposure (1.2, 1.0, 1.1, and 1.1 mm/Hg, respectively). Intermittent PA compared with rest was associated with lower SBP post-exposure (-2.4 mm/Hg, p<0.001). PA lowered SBP more after exposure to the low-TRAP site (-2.3 mm/Hg) compared with the high-TRAP site (-1.6 mm/Hg). We only found evidence of an interaction between PA and both PM10 and PMcoarse, increasing SBP. Conclusion: Both SBP and DBP increase after exposure to TRAP. Intermittent PA attenuates the TRAP-related increases in SBP, with the exception of PM10 and PMcoarse, which potentiate these increases. We showed that in low-TRAP environments intermittent PA has stronger beneficial effects on SBP than in high-TRAP environments.

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