Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Patricia Klobusiakova, Jiri Mekyska, Lubos Brabenec, Zoltan Galaz, Vojtech Zvoncak, Jan Mucha, Steven Z. Rapcsak, Irena Rektorova

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.

Original languageEnglish (US)
Pages (from-to)122-128
Number of pages7
JournalParkinsonism and Related Disorders
Volume84
DOIs
StatePublished - Mar 2021

Keywords

  • Acoustic analysis
  • Hypokinetic dysarthria
  • Parkinson's disease
  • Resting-state functional connectivity
  • Voxel-based morphometry
  • fMRI

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures'. Together they form a unique fingerprint.

Cite this