Artificial lung prototype development

Scott D Lick, S. K. Alpard, P. Montoya, D. J. Deyo, J. B. Jayroe, J. B. Zwischenberger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

Original languageEnglish (US)
Pages (from-to)230
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
StatePublished - Mar 2000
Externally publishedYes

Fingerprint

Blood
Sheep
Lung
Exsanguination
Pulmonary Artery
Gases
Transplants
Medical Errors
Heart-Assist Devices
Nuts
Flow patterns
Animals
Sampling
Membranes
Recovery
Thorax
Heart Failure
Fibers
Cannula

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Lick, S. D., Alpard, S. K., Montoya, P., Deyo, D. J., Jayroe, J. B., & Zwischenberger, J. B. (2000). Artificial lung prototype development. ASAIO Journal, 46(2), 230.

Artificial lung prototype development. / Lick, Scott D; Alpard, S. K.; Montoya, P.; Deyo, D. J.; Jayroe, J. B.; Zwischenberger, J. B.

In: ASAIO Journal, Vol. 46, No. 2, 03.2000, p. 230.

Research output: Contribution to journalArticle

Lick, SD, Alpard, SK, Montoya, P, Deyo, DJ, Jayroe, JB & Zwischenberger, JB 2000, 'Artificial lung prototype development', ASAIO Journal, vol. 46, no. 2, pp. 230.
Lick SD, Alpard SK, Montoya P, Deyo DJ, Jayroe JB, Zwischenberger JB. Artificial lung prototype development. ASAIO Journal. 2000 Mar;46(2):230.
Lick, Scott D ; Alpard, S. K. ; Montoya, P. ; Deyo, D. J. ; Jayroe, J. B. ; Zwischenberger, J. B. / Artificial lung prototype development. In: ASAIO Journal. 2000 ; Vol. 46, No. 2. pp. 230.
@article{244a0393295b446aba71c4474a113240,
title = "Artificial lung prototype development",
abstract = "We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.",
author = "Lick, {Scott D} and Alpard, {S. K.} and P. Montoya and Deyo, {D. J.} and Jayroe, {J. B.} and Zwischenberger, {J. B.}",
year = "2000",
month = "3",
language = "English (US)",
volume = "46",
pages = "230",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Artificial lung prototype development

AU - Lick, Scott D

AU - Alpard, S. K.

AU - Montoya, P.

AU - Deyo, D. J.

AU - Jayroe, J. B.

AU - Zwischenberger, J. B.

PY - 2000/3

Y1 - 2000/3

N2 - We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

AB - We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

UR - http://www.scopus.com/inward/record.url?scp=0034158866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034158866&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 230

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 2

ER -