Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Minkyu Kim, Wesley G. Chen, Jeon Woong Kang, Matthew J. Glassman, Katharina Ribbeck, Bradley D. Olsen

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.

Original languageEnglish (US)
Pages (from-to)4207-4212
Number of pages6
JournalAdvanced Materials
Volume27
Issue number28
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • bioinspired materials
  • hydrogels
  • protein polymer design
  • selective permeability

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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