Ascorbic acid absorption in humans: A comparison among several dosage forms

Susanna Yung, Michael Mayersohn, J. Barry Robinson

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

There have been few studies conducted to determine the efficiency of ascorbic acid absorption in humans. Differences in the extent of its absorption among individuals may contribute to the outcome of clinical trials. Ascorbic acid absorption in four subjects was investigated from several oral dosage forms containing 1 g of the vitamin (solution, tablet, chewable tablet, and timed‐release capsule). Approximately 85% of an intravenous dose was recovered in the urine as ascorbic acid and its major metabolites. In contrast, only ∼30% of the dose was recovered from the solution and tablet forms. A considerably smaller fraction of the dose (∼14%) was recovered from the timed‐release capsule. There was considerable intersubject variation in ascorbic acid absorption and there appeared to be good and poor absorbers of the vitamin. Consideration should be given to the influence of the extent of ascorbic acid absorption on the results of clinical trials.

Original languageEnglish (US)
Pages (from-to)282-285
Number of pages4
JournalJournal of pharmaceutical sciences
Volume71
Issue number3
DOIs
StatePublished - Mar 1982

Keywords

  • Absorption—ascorbic acid, comparison of several dosage forms, humans
  • Ascorbic acid—comparison of absorption of several dosage forms, humans
  • Vitamin C—comparison of absorption of several dosage forms, humans

ASJC Scopus subject areas

  • Pharmaceutical Science

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