Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia

Timothy R H Regnault, Sean W Limesand, William W. Hay

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Newborn birth weights have been steadily increasing throughout much of the developed world.1-3 However, the numbers of the two extremes, small fetuses that have suffered some form of intrauterine growth restriction (IUGR) and large or macrosomic fetuses, remain constant, and within some populations are actually increasing. IUGR and large-for-gestational-age (LGA) fetuses and newborns are at increased risk for fetal and neonatal morbidity and mortality.7, 8 IUGR is an important and relatively common problem in obstetrics, which may represent impaired placental insufficiency and associated placental nutrient transport function. In developed countries, 3-7% of newborns are classified as IUGR, 9 the causes of which include, but are not limited to, maternal malnutrition, maternal hypertension and idiopathic placental insufficiency. These fetuses are at increased risk of hypoxia, hypoglycemia and acidemia and also spontaneous preterm delivery. Interest in IUGR has increased recently by retrospective epidemiological, clinical follow-up and animal studies, 13, 14 that indicate increased susceptibility to adulthood metabolic disorders such as obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease, particularly hypertension, in IUGR offspring.15-18 Furthermore, follow-up studies of infants who displayed abnormal umbilical artery Doppler flow velocity waveforms, commonly associated with IUGR, have demonstrated a lower IQ at 3 and 5 years of age. At the other end of the spectrum, the number of macrosomic, LGA births among certain minorities, delivered at term or ≥ 41 weeks, has increased.

Original languageEnglish (US)
Title of host publicationNeonatal Nutrition and Metabolism, Second Edition
PublisherCambridge University Press
Pages32-46
Number of pages15
ISBN (Print)9780511544712, 0521824559, 9780521824552
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Growth
Fetus
Placental Insufficiency
Newborn Infant
Gestational Age
Mothers
Hypertension
Umbilical Arteries
Hypoglycemia
Developed Countries
Birth Weight
Malnutrition
Type 2 Diabetes Mellitus
Obstetrics
Insulin Resistance
Cardiovascular Diseases
Obesity
Parturition
Morbidity
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Regnault, T. R. H., Limesand, S. W., & Hay, W. W. (2006). Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia. In Neonatal Nutrition and Metabolism, Second Edition (pp. 32-46). Cambridge University Press. https://doi.org/10.1017/CBO9780511544712.004

Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia. / Regnault, Timothy R H; Limesand, Sean W; Hay, William W.

Neonatal Nutrition and Metabolism, Second Edition. Cambridge University Press, 2006. p. 32-46.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regnault, TRH, Limesand, SW & Hay, WW 2006, Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia. in Neonatal Nutrition and Metabolism, Second Edition. Cambridge University Press, pp. 32-46. https://doi.org/10.1017/CBO9780511544712.004
Regnault TRH, Limesand SW, Hay WW. Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia. In Neonatal Nutrition and Metabolism, Second Edition. Cambridge University Press. 2006. p. 32-46 https://doi.org/10.1017/CBO9780511544712.004
Regnault, Timothy R H ; Limesand, Sean W ; Hay, William W. / Aspects of fetoplacental nutrition in intrauterine growth restriction and macrosomia. Neonatal Nutrition and Metabolism, Second Edition. Cambridge University Press, 2006. pp. 32-46
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