Aspiration in children with CHARGE syndrome

David R. White, Barbara K. Giambra, Robert J. Hopkin, Cori L Daines, Michael J. Rutter

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Patients with Coloboma, Heart defect, choanal Atresia, Retarded development, Genitorenal and Ear abnormalities (CHARGE) syndrome have been reported to be at high risk for aspiration and swallowing difficulties. Aspiration has been implicated as the most common cause of mortality in these patients. To date, however, aspiration and swallowing disorders in CHARGE patients have not been independently studied. Objective: To determine the prevalence of aspiration and swallowing dysfunction in children with CHARGE syndrome. Methods: A retrospective chart review of 30 children with CHARGE syndrome was performed. Results: Eighteen (60%) children had aspiration observed on video swallow study (VSS), flexible endoscopic evaluation of swallowing (FEES), and/or had otherwise unexplained bronchiectasis noted on CT scan of the chest. Twenty-four children (80%) had evidence of abnormal swallowing such as laryngeal penetration, dyscoordination, poor bolus mobility, or pooling of secretions. Conclusion: Aspiration and swallowing dysfunction are common in children with CHARGE syndrome. Formal evaluation of swallowing function should be part of the standard otolaryngologic examination for these patients.

Original languageEnglish (US)
Pages (from-to)1205-1209
Number of pages5
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume69
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Choanal Atresia
Deglutition
Ear
Coloboma
Bronchiectasis
Ataxia
Deglutition Disorders
Thorax
Mortality

Keywords

  • Aspiration
  • CHARGE syndrome
  • Laryngomalacia
  • Supraglottoplasty

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Aspiration in children with CHARGE syndrome. / White, David R.; Giambra, Barbara K.; Hopkin, Robert J.; Daines, Cori L; Rutter, Michael J.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 69, No. 9, 09.2005, p. 1205-1209.

Research output: Contribution to journalArticle

White, David R. ; Giambra, Barbara K. ; Hopkin, Robert J. ; Daines, Cori L ; Rutter, Michael J. / Aspiration in children with CHARGE syndrome. In: International Journal of Pediatric Otorhinolaryngology. 2005 ; Vol. 69, No. 9. pp. 1205-1209.
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