Aspochalasins I, J, and K: Three New Cytotoxic Cytochalasans of Aspergillus flavipes from the Rhizosphere of Ericameria laricifolia of the Sonoran Desert

Guang Xiong Zhou, E. M.Kithsiri Wijeratne, Donna Bigelow, Leland S. Pierson, Hans D. VanEtten, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalJournal Of Natural Products
Volume67
Issue number3
DOIs
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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