Aspochalasins I, J, and K: Three New Cytotoxic Cytochalasans of Aspergillus flavipes from the Rhizosphere of Ericameria laricifolia of the Sonoran Desert

Guang Xiong Zhou, E. M Kithsiri Wijeratne, Donna Bigelow, Leland S. Pierson, Hans D. VanEtten, Leslie Gunatilaka

Research output: Contribution to journalArticle

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Abstract

Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalJournal of Natural Products
Volume67
Issue number3
DOIs
StatePublished - Mar 2004

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Aspergillus flavipes
Ericameria
Sonoran Desert
Rhizosphere
Spectroscopic analysis
Bioassay
Aspergillus
Cytotoxicity
Fractionation
Biological Assay
cytotoxicity
fractionation
rhizosphere
bioassays
Cells
cell lines
Nuclear magnetic resonance
Cell Line
extracts
Neoplasms

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Aspochalasins I, J, and K : Three New Cytotoxic Cytochalasans of Aspergillus flavipes from the Rhizosphere of Ericameria laricifolia of the Sonoran Desert. / Zhou, Guang Xiong; Wijeratne, E. M Kithsiri; Bigelow, Donna; Pierson, Leland S.; VanEtten, Hans D.; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 67, No. 3, 03.2004, p. 328-332.

Research output: Contribution to journalArticle

Zhou, Guang Xiong ; Wijeratne, E. M Kithsiri ; Bigelow, Donna ; Pierson, Leland S. ; VanEtten, Hans D. ; Gunatilaka, Leslie. / Aspochalasins I, J, and K : Three New Cytotoxic Cytochalasans of Aspergillus flavipes from the Rhizosphere of Ericameria laricifolia of the Sonoran Desert. In: Journal of Natural Products. 2004 ; Vol. 67, No. 3. pp. 328-332.
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