Assessing ectasia susceptibility prior to LASIK: The role of age and residual stromal bed (RSB) in conjunction to Belin-Ambrósio deviation index (BAD-D)

Renato Ambrósio, Isaac Ramos, Bernardo Lopes, Ana Laura Caiado Canedo, Rosane Correa, Frederico Guerra, Allan Luz, Francis W. Price, Marianne O. Price, Steven Schallhor, Michael W Belin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To compare the ability to detect preoperative ectasia risk among LASIK candidates using classic ERSS (Ectasia Risk Score System) and Pentacam Belin-Ambrósio deviation index (BAD-D), and to test the benefit of a combined approach including BAD-D and clinical data. Methods: A retrospective nonrandomized study involved preoperative LASIK data from 23 post-LASIK ectasia cases and 266 stable-LASIK (follow up > 12 months). Preoperative clinical and Pentacam (Oculus; Wetzlar, Germany) data were obtained from all cases. Mann-Whitney's test was performed to assess differences between groups. Stepwise logistic regression was used for combining parameters. The areas under the Receiver Operating Characteristic (ROC) curves (AUC) were calculated for all parameters and combinations, with pairwise comparisons of AUC (DeLong's method). Results: Statistically significant differences were found for age, residual stromal bed (RSB), central corneal thickness and BAD-D (p<0.001), but not for sphere, cylinder or spherical equivalent (p>0.05). ERSS was 3 or more on 12/23 eyes from the ectasia group (sensitivity = 52.17%) and 48/266 eyes from the stable LASIK group (18% false positive). BAD-D had AUC of 0.931 (95% CI: 0.895 to 0.957), with cut-off of 1.29 (sensitivity = 87%; specificity = 92.1%). Formula combining BAD-D, age and RSB provided 100% sensitivity and 94% specificity, with better AUC (0.989; 95% CI: 0.969 to 0.998) than all individual parameters (p>0.001). Conclusion: BAD-D is more accurate than ERSS. Combining clinical data and BAD-D improved ectasia susceptibility screening. Further validation is necessary. Novel combined functions using other topometric and tomographic parameters should be tested to further enhance accuracy.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalRevista Brasileira de Oftalmologia
Volume73
Issue number2
DOIs
StatePublished - 2014

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Pathologic Dilatations
Laser In Situ Keratomileusis
Area Under Curve
ROC Curve
Germany
Retrospective Studies
Logistic Models
Sensitivity and Specificity

Keywords

  • Corneal diseases/etiology
  • Corneal topography
  • Dilatation pathologic/etiology
  • Keratomileusis laser in situ/adverse effects

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Assessing ectasia susceptibility prior to LASIK : The role of age and residual stromal bed (RSB) in conjunction to Belin-Ambrósio deviation index (BAD-D). / Ambrósio, Renato; Ramos, Isaac; Lopes, Bernardo; Canedo, Ana Laura Caiado; Correa, Rosane; Guerra, Frederico; Luz, Allan; Price, Francis W.; Price, Marianne O.; Schallhor, Steven; Belin, Michael W.

In: Revista Brasileira de Oftalmologia, Vol. 73, No. 2, 2014, p. 75-80.

Research output: Contribution to journalArticle

Ambrósio, Renato ; Ramos, Isaac ; Lopes, Bernardo ; Canedo, Ana Laura Caiado ; Correa, Rosane ; Guerra, Frederico ; Luz, Allan ; Price, Francis W. ; Price, Marianne O. ; Schallhor, Steven ; Belin, Michael W. / Assessing ectasia susceptibility prior to LASIK : The role of age and residual stromal bed (RSB) in conjunction to Belin-Ambrósio deviation index (BAD-D). In: Revista Brasileira de Oftalmologia. 2014 ; Vol. 73, No. 2. pp. 75-80.
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abstract = "Purpose: To compare the ability to detect preoperative ectasia risk among LASIK candidates using classic ERSS (Ectasia Risk Score System) and Pentacam Belin-Ambr{\'o}sio deviation index (BAD-D), and to test the benefit of a combined approach including BAD-D and clinical data. Methods: A retrospective nonrandomized study involved preoperative LASIK data from 23 post-LASIK ectasia cases and 266 stable-LASIK (follow up > 12 months). Preoperative clinical and Pentacam (Oculus; Wetzlar, Germany) data were obtained from all cases. Mann-Whitney's test was performed to assess differences between groups. Stepwise logistic regression was used for combining parameters. The areas under the Receiver Operating Characteristic (ROC) curves (AUC) were calculated for all parameters and combinations, with pairwise comparisons of AUC (DeLong's method). Results: Statistically significant differences were found for age, residual stromal bed (RSB), central corneal thickness and BAD-D (p<0.001), but not for sphere, cylinder or spherical equivalent (p>0.05). ERSS was 3 or more on 12/23 eyes from the ectasia group (sensitivity = 52.17{\%}) and 48/266 eyes from the stable LASIK group (18{\%} false positive). BAD-D had AUC of 0.931 (95{\%} CI: 0.895 to 0.957), with cut-off of 1.29 (sensitivity = 87{\%}; specificity = 92.1{\%}). Formula combining BAD-D, age and RSB provided 100{\%} sensitivity and 94{\%} specificity, with better AUC (0.989; 95{\%} CI: 0.969 to 0.998) than all individual parameters (p>0.001). Conclusion: BAD-D is more accurate than ERSS. Combining clinical data and BAD-D improved ectasia susceptibility screening. Further validation is necessary. Novel combined functions using other topometric and tomographic parameters should be tested to further enhance accuracy.",
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T2 - The role of age and residual stromal bed (RSB) in conjunction to Belin-Ambrósio deviation index (BAD-D)

AU - Ambrósio, Renato

AU - Ramos, Isaac

AU - Lopes, Bernardo

AU - Canedo, Ana Laura Caiado

AU - Correa, Rosane

AU - Guerra, Frederico

AU - Luz, Allan

AU - Price, Francis W.

AU - Price, Marianne O.

AU - Schallhor, Steven

AU - Belin, Michael W

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