Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose

Frank Schraml, Kewei Chen, Napatkamon Ayutyanont, Roontiva Auttawut, Jessica B S Langbaum, Wendy Lee, Xiaofen Liu, Dan Bandy, Stephanie Q. Reeder, Gene E Alexander, Richard J. Caselli, Adam S. Fleisher, Eric M. Reiman

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Abstract

Background:We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.Methods:An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.Results:These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).Conclusions:The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.

Original languageEnglish (US)
Article numbere67163
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 26 2013

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Schraml, F., Chen, K., Ayutyanont, N., Auttawut, R., Langbaum, J. B. S., Lee, W., ... Reiman, E. M. (2013). Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. PLoS One, 8(6), [e67163]. https://doi.org/10.1371/journal.pone.0067163