Association between body composition and hip fractures in older women with physical frailty

Oleg Zaslavsky, Wenjun Li, Scott B Going, Mridul Datta, Linda Snetselaar, Shira Zelber-Sagi

Research output: Contribution to journalArticle

4 Scopus citations


Aim: We sought to determine the extent to which higher lean and fat mass as measured by dual X-ray absorptiometry in older adults with frailty are related to total hip bone mass density (BMD) index and the rate of hip fractures. Methods: The data are from the Women's Health Initiative Observational Study. We identified 872 participants aged ≥65years with body composition measures and positive frailty. Frailty was determined using modified Fried's criteria. Linear and Cox regressions were used to model study outcomes. Results: During the follow-up period, 5.6% patients (n=49) had sustained a hip fracture. Body composition indexes were associated with total hip BMD (P2 increase in fat mass was 0.73 (95% confidence interval 0.60-0.88) for appendicular compartment, 0.76 (95% confidence interval 0.65-0.89) for trunk and 0.84 (95% confidence interval 0.77-0.93) for whole-body fat mass. The hazard ratio for hip fracture per 1kg/m2 increase in appendicular lean mass was 0.63 (95% confidence interval 0.46-0.88). However, after final adjustment for total hip BMD, the only index that remained statistically significant was whole-body fat mass (P for trend=0.04). Conclusions: We showed that in frail older women, higher fat and lean mass was associated with reduced hip-fracture rates. Higher whole-body adiposity, however, was also associated with lower hip-fracture rate independent of total hip BMD. The present results confirm the importance of weight maintenance in frail populations.

Original languageEnglish (US)
JournalGeriatrics and Gerontology International
Publication statusAccepted/In press - 2016



  • Bone
  • Fat mass
  • Frailty
  • Hip fracture
  • Lean mass

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

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